6th The Awaji International Forum on Infection and Immunity
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Fidel P. Zavala, M.D.

Professor
Department Molecular Microbiology and Immunology
Bloomberg School of Public Health
Johns Hopkins University
Educations

1976 M.D. University of Chile School of Medicine, Santiago, Chilie
1980 Postdoc New York University School of Medicine, New York, NY

Positions

1980-1982 Post-Doctoral Fellow, Department of Microbiology, New York University Medical Center, New York, NY
1982-1984 Research Assistant Professor, Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY
1984-1991 Assistant Professor, Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY
1992-2000 Associate Professor, Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY
2000-2003 Professor, Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, NY
2003-Present Professor, Department Molecular Microbiology and Immunology. Bloomberg School of Public Health. Johns Hopkins University

Selected Publications (70 additional publications)

Tsuji, M., Miyahira, Y., Nussenzweig, R.S., Aguet, M., Reichel, M. and Zavala, F. 1995. Development of anti-malaria immunity in mice lacking IFN-γ receptor. J. Immunol. 154: 5338-5344.

Murata, K., Garcia-Sastre, A., Tsuji, M., Rodrigues, M., Rodrigues, D., Rodriguez, J.R., Nussenzweig, R.S., Palese, P., Esteban, M. and Zavala, F. 1996. Characterization of in vivo primary and secondary CD8+ T cell responses induced by recombinant influenza and vaccinia viruses. Cell. Immunol. 173: 96-107.

Takita-Sonada, Y., Tsuji, M., Kamboj, K., Nussenzweig, R.S., Clavijo, P. and Zavala, F. 1996. Plasmodium yoelli: Peptide immunization induces protective CD4+ T cells against a previously unrecognized cryptic epitope of the CS protein. Exp. Parasitol. 84: 223-230.

Tsuji, M., Cassandra, L.E., Eyster, C. O’Brien, R.L., Born, W.K., Reichel, M., Nussenzweig, R.S. and Zavala, F. 1996. Phenotypic and functional properties of murine γδ T cell clones derived from malaria immunized, αβ T cell-deficient mice. Int. Immunol. 8: 359-366.

Rodrigues, E.G., Zavala, F., Eichinger, D., Wilson, J.M. and Tsuji, M. 1997. Single immunizing dose of recombinant adenovirus efficiently induces CD8+ T cell-mediated protective immunity against malaria. J. Immunol. 158: 1268-1274.

Nussenzweig, R.S. and Zavala, F. 1997. A malaria vaccine based on a sporozoite antigen. A malaria vaccine based on a sporozoite antigen. (Editorial). New Eng. J. Med. 336(2): 28-129.

Palese, P., Zavala, F., Muster, T. and Garcia-Sastre, A. 1997. Development of influenza virus vaccines and vectors. J. Infect. Diseases 176 (Suppl 1): S45-9.

Miyahira, Y., Garcia-Sastre, A., Rodriguez, J.R., Rodriguez, D., Murata, K., Tsuji, M., Esteban, M., Palese, P., Zavala, F. and Nussenzweig, R.S. 1998. Recombinant viruses expressing a human malaria antigen elicited protective cellular and humoral responses in mice. Proc. Natl. Acad. Sci., USA 95: 3954-3959.

Tsuji, M., Bergmann, C.C., Takita-Sonoda, Y., Murata, K. Rodrigues, E.G., Nussenzweig, R.S. and Zavala, F. 1998. Recombinant Sindbis viruses expressing a cytotoxic T lymphocyte epitope of a malaria parasite or of an influenza virus elicit protection against the corresponding pathogen in mice. J. Virol. 72: 6907-6910.

Rodrigues, E.G., Zavala, F., Nussenzweig, R.S., Wilson, J.M. and Tsuji, M. 1998. Efficient reduction of protective anti-malaria immunity by recombinant . Vaccine 16:1812-1617.

Fernandez, J.A., Zavala, F. and Tsuji, M. 1999. Phenotypic and functional characterization of CD8+ T cell clones specific for a mouse cytomegalovirus epitope. Virology 155: 40-49.

Magdalena Gherardi, M., Ramirez, J.C., Rodriguez, D., Rodriguez, J.R., Sano, G-I, Zavala, F. and Esteban, M. 1999. IL-12 delivery from recombinant vaccinia virus attenuates the vector and enhances the cellular immune response against HIV-1 enc in a dose-dependent manner. J. Immunol. 162: 6724-6733.

Ferreira, J. Myahira, Y., Roriguez, J.R., Rodriguez, D., Nussenzweig, R.S., Esteban, M. and Zavala,F. 2000. Immunogenicity of Ty-VLP bearing a CD8+ T cell epitope of the CS protein of P. yoelii: Enhanced memory response by boosting with recombinant vaccinia virus. Vaccine 18: 1863-1869.

Zavala F., Rodrigues M., Rodriguez D. Rodriguez J.R., Nussenzweig R.S., and Esteban M. 2001. A striking property of recombinant poxviruses: efficient inducers of in vivo expansion of primed CD8+ T cells. Virology 280: 55-159

Bruna-Romero O.B., Hafalla J.C., Gonzales Gloria., Sano, G., Tsuji M. and Zavala F. 2001 Detection of malaria liver stages in mice infected through the bite of a single Anopheles mosquitoes using a highly sensitive real-time PCR. Int. J. Parasitology 31:1499-1502

Sano G., Hafalla J.C., Morrot A., Abe R., Lafaille J., and Zavala F. 2001. Swift development of protective effector functions in naïve CD8+ T cells against malaria liver stages. J. Exp. Med. 194:173-179

Carvalho, L.H., Sano,G.,Hafalla J.C, Morrot A., Curotto M. and Zavala F. 2002. IL-4 secreting CD4+ T cells are crucial to the development ofCD8+ T cell responses against malaria liver stages. Nature. Med. 8(2):166-170

Jung, S. , Unutmaz D., Wong D. .P, Sano G. I., De los Santos K., Sparwasser T., Wu S., Zavala, F., Pamer E.G., Littman D.R. and Lang R. 2002. Abrogation of Cytotoxic T cell Cross Priming by Induced In vivo Ablation of CD11c+ Dendritic Cells. Immunity 17:211-220

Hafalla, JC., Sano. G, Carvalho L., Morrrot A., and Zavala F. 2002. Short-term antigen presentation and single clonal burst limit the magnitude of the CD8+ T cell responses against malaria liver stages. Proc. Natl. Acad. Sci.. (USA) 99:11819-11824

Hafalla, J.C., Morrot. A., Sano G., Milon G., Lafaille J.J.and Zavala F.2003. Early self-regulatory mechanisms control the magnitude of the CD8+ T cell responses against liver stages of murine malaria. J. Immunol. 171(2):964-70.

Morrot and Zavala F. 2004. Regulation of CD8+ T cell responses against Plasmodium live in mice Int. J. Parasitol 34: 1529-1534

Del Portillo H, Lanzer M., Rodriguez-Malaga S, Zavala F and Fernandez Becerra C. 2004.Variant genes and the spleen in Plasmodium vivax malaria. Int. J. Parasitol. 34 1547-1554 genes and the spleen in Plasmodium vivax malaria. Int. J. Parasitol. 34 1547-1554

Tongren, JE., Zavala F., Roos DS., and Riley E.M. 2004. Malaria vaccines: if at first you don’t succeed. Trends in Parasitol. 20:604-610

Morrot, A. and Zavala, F. 2004 Effector and memory CD8+ T cell as seen in immunity to malaria liver stages . Immunol. Revs. 201:291-303

Morrot, A., Hafalla J.C., Cockburn I.A., Carvalho L.H., and Zavala F. 2005. IL-4 R expression is required for the development of protective memory responses against liver stages of malaria parasites. J. Exp Med. 202(4):551-60.

Hafalla JC, Cockburn IA, and Zavala F. 2006. Protective and Pathogenic roles of CD8+ T cells during malaria infection. Parasite Immunol. 28:15-24

Boscardin AB, Hafalla JCR, Masilamani RF, Kamphorst, AO, Zebroski, HA Rai U, Morrot A, Zavala F, Steinman RM, Nussenzweig, RS and Nussenzweig MC. 2006. Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses. J. Exp. Med. 203: 599-606

Morrot A, Ian A. Cockburn, Michael Overstreet, Dolores Rodríguez and Fidel Zavala. 2006. Protective CD8+ T cells induced by malaria sporozoites do not undergo modulation of IL-7 receptor expression. Infect. Immun. 74: 2495-2497

Hafalla JC, Urvashi Rai, Alexandre Morrot, Dabeiba Bernal-Rubio, Fidel Zavala and Ana Rodriguez. 2006 Priming of CD8+ T cell responses following immunization with heat-killed Plasmodium sporozoites. Eur. J Immunol 36:1179-86.
 
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