The 6th Awaji International Forum on Infection and Immunity

Naoki Yamamoto, M.D., Ph.D.

Director
National Institute of Infectious Diseases
AIDS Research Center
1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan

Professor emeritus
Tokyo Medical and Dental University
Department of Molecular Virology
1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan

Education

1964-1970	Kumamoto Univ. School of Med., Japan (M.D.)
1971-1975	Graduate Division, Kumamoto Univ. School of Med., Japan (Microbiology) (Ph.D.)

Occupational History: the major positions I have held starting from the most recent.

2001-present	Director, AIDS Research Center, National Institute of Infectious Diseases
1990-present	Professor and Chairman, Dept. of Microbiology, Tokyo Med. Dent. Univ. Sch. of Med.
1984-1990	Professor and Chairman, Dept. of Virology and Parasitology, Yamaguchi Univ. School of Med.
1981-1984	Assistant Professor, Dept. of Prevention and Therapeutics, Inst. for Virus Res.,　Kyoto Univ.
1979-1981	”Wissenshaftlicher Angestellter”, Inst.fur Virologie, Zentrum fur Hygiene,Univ. Freiburg, West Germany
1975-1980	Assistant Professor, Dept. of Microbiology, Kumamoto Univ. School of Med.

Recent publications
2006

1.Eda Y, Murakami T, Ami Y, Nakasone T, Takizawa M, Someya K, Kaizu M, Izumi Y, Yoshino N, Matsushita S, Higuchi H, Matsui H, Shinohara K, Takeuchi H, Koyanagi Y, Yamamoto N, Honda M. Anti-V3 Humanized Antibody KD-247 Effectively Suppresses Ex Vivo Generation of Human Immunodeficiency Virus Type 1 and Affords Sterile Protection of Monkeys against a Heterologous Simian/Human Immunodeficiency Virus Infection. J Virol. 2006 Jun;80(11):5563-70.

2. Eda Y, Takizawa M, Murakami T, Maeda H, Kimachi K, Yonemura H, Koyanagi S, Shiosaki K, Higuchi H, Makizumi K, Nakashima T, Osatomi K, Tokiyoshi S, Matsushita S, Yamamoto N, Honda M. Sequential Immunization with V3 Peptides from Primary Human Immunodeficiency Virus Type 1 Produces Cross-Neutralizing Antibodies against Primary Isolates with a Matching Narrow-Neutralization Sequence Motif. J Virol. 2006 Jun;80(11):5552-62.

3. Saito T, Tun-Kyi A, Ryo A, Yamamoto M, Finn G, Fujita T, Akira S, Yamamoto N, Lu K-P, Yamamoka S. Peptidyl-Prolyl Isomerase Pin1 regulates interferon regulatory factor 3 signaling to innate antiviral response. Nature Immunol. 2006 Jun;7(6):598-605.

4. Dewan MZ, Uchihara JN, Terashima K, Honda M, Sata T, Ito M, Fujii N, Uozumi, K, Tsukasaki K, Tomonaga M, Kubuki Y, Okayama A, Toi M, Mori N, Yamamoto N.
Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir.Blood.2006Jan15;107(2):716-24.

2005

1. Someya, K., Cecilia, D., Ami, Y., Nakasone, T., Matsuo, K., Burda, S., Yamamoto, H., Yoshino, N., Kaizu, M., Ando, S., Okuda, K., Zolla-Pazner, S., Yamazaki, S., Yamamoto, N., and Honda, M. Vaccination of Rhesus Macaques with Recombinant Mycobacterium bovis Bacillus Calmette-Guerin Env V3 Elicits Neutralizing Antibody-Mediated Protection against Simian-Human Immunodeficiency Virus with a Homologous but Not a Heterologous V3 Motif. J Virol. 2005, 79, 1452-1462.

2. Saitoh, T., Yamamoto, M., Miyagishi, M., Taira, K., Nakanishi, M., Fujita, T., Akira, S., Yamamoto, N., and Yamaoka, S. A20 is a negative regulator of IFN regulatory factor 3 signaling. J Immunol. 2005, 174, 1507-1512.

3. Miyauchi, K., Komano, J., Yokomaku, Y., Sugiura, W., Yamamoto, N., and Matsuda, Z. Role of the specific amino acid sequence of the membrane-spanning domain of human immunodeficiency virus type 1 in membrane fusion. J Virol. 2005, 79, 4720-4729.

4. Nonaka, M., Horie, R., Itoh, K., Watanabe, T., Yamamoto, N., and Yamaoka, S.
Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts. Oncogene. 2005 Jun 2;24(24):3976-86.

2004

1. Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature. 2004 Jul 8;430(6996):218-22.

2. Mori, N., Matsuda, T., Tadano, M., Kinjo, T., Yamada, Y., Tsukasaki, K., Ikeda, S., Yamasaki, Y., Tanaka, Y., Ohta, T., Iwamasa, T., Tomonaga, M., and Yamamoto, N. Apoptosis Induced by the Histone Deacetylase Inhibitor FR901228 in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines and Primary Adult T-Cell Leukemia Cells. J Virol. 2004, 78, 4582-4590.

3. Someya, K., Xin, K.Q., Matsuo, K., Okuda, K., Yamamoto, N., and Honda, M. A consecutive priming-boosting vaccination of mice with simian immunodeficiency virus (SIV) gag/pol DNA and recombinant vaccinia virus strain DIs elicits effective anti-SIV immunity. J Virol. 2004, 78, 9842-9853.

4. Mori, N., Matsuda, T., Tadano, M., Kinjo, T., Yamada, Y., Tsukasaki, K., Ikeda, S., Yamasaki,Y., Tanaka, Y., Ohta, T., Iwamasa, T., Tomonaga, M., and Yamamoto, N. Apoptosis Induced by the Histone Deacetylase Inhibitor FR901228 in Human T-Cell Leukemia Virus Type1-Infected T-Cell Lines and Primary Adult T-Cell Leukemia Cells. J Virol. 2004, 78, 4582-4590.