6th The Awaji International Forum on Infection and Immunity
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Kiyoshi Takeda, M.D., Ph.D.

Department of Molecular Genetics
Medical Institute of Bioregulation
Kyushu University
3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

1986-1992 Osaka University, Medical School
obtained M.D. degree at 1992
1994-1998 Osaka University,
obtained Ph.D. degree at 1998

1992 Medical Doctor; Internal Medicine at Hospital of Osaka University Medical School, Osaka, Japan
1993 Medical Doctor; Internal Medicine at Kinki Central Hospital, Hyogo, Japan

1998 Research Associate; Department of Biochemistry, Hyogo College of Medicine, Hyogo, Japan
1999-2003 Research Associate; Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
2003-present Professor; Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University

Kuwata, K., Matsumoto, M., Atarashi, K., Morishita, H., Hirotani, T., Koga, R., and Takeda, K.: IκBNS inhibits induction of a subset of Toll-like receptor-dependent genes and limits inflammation. Immunity 24, 41-51 (2006).

Hirotani, T., Lee, P. Y., Kuwata, H., Yamamoto, M., Matsumoto, M., Kawase, I., Akira, S., and Takeda, K.: The nuclear IκB protein IκBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria. J. Immunol. 174, 3650-3657 (2005).

Kobayashi, M., Kweon, M., Kuwata, H., Kiyono, H., Takeda, K., and Akira, S.: Toll-like receptor-dependent IL-12p40 production causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J. Clin. Invest. 111, 1297-1308 (2003).

Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., and Akira, S.: Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science 301, 640-643 (2003).

Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S., Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita, T., Takeda, K., and Akira, S.: Essential role for TIRAP in activation of the signaling cascade shared by TLR2 and TLR4. Nature 420, 324-329 (2002).

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Hoshino, K., Wagner, H., Takeda, K., and Akira, S.: A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745 (2000).

Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., and Akira, S.: Limb and skin abnormalities in mice lacking IKKα. Science 284, 313-316 (1999).

Takeda, K., Clausen, B., Kaisho, T., Tsujimura, T., Terada, N., Forster, I., and Akira, S.: Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10, 39-49 (1999).

Takeda, K., Tsutsui, H., Yoshimoto, T., Adachi, O., Yoshida, N., Kishimoto, T., Okamura, H., Nakanishi, K., and Akira, S.: Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity, 8, 383-390 (1998).

Takeda, K., Tanaka,T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S., Nakanishi, K., Yoshida, N., Kishimoto, T., and Akira, S.: Essential role of Stat6 in IL-4 signalling. Nature 380, 627-630 (1996).
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