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Kiyoshi Takeda, M.D., Ph.D.
Professor
Department of Molecular Genetics
Medical Institute of Bioregulation
Kyushu University
3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan |
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EDUCATION
| 1986-1992 |
Osaka University, Medical School
obtained M.D. degree at 1992 |
| 1994-1998 |
Osaka University,
obtained Ph.D. degree at 1998 |
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HOSPITAL POSITION
| 1992 |
Medical Doctor; Internal Medicine at Hospital
of Osaka University Medical School, Osaka, Japan |
| 1993 |
Medical Doctor; Internal Medicine at Kinki Central Hospital,
Hyogo, Japan |
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ACADEMIC POSITION
| 1998 |
Research Associate; Department of Biochemistry,
Hyogo College of Medicine, Hyogo, Japan |
| 1999-2003 |
Research Associate; Department of Host Defense, Research
Institute for Microbial Diseases, Osaka University, Osaka,
Japan |
| 2003-present |
Professor; Department of Molecular Genetics, Medical Institute
of Bioregulation, Kyushu University |
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SELECTED PUBLICATIONS
Kuwata, K., Matsumoto, M., Atarashi, K., Morishita,
H., Hirotani, T., Koga, R., and Takeda, K.:
IκBNS inhibits induction of a subset of Toll-like receptor-dependent
genes and limits inflammation. Immunity 24, 41-51
(2006).
Hirotani, T., Lee, P. Y., Kuwata, H., Yamamoto, M., Matsumoto,
M., Kawase, I., Akira, S., and Takeda, K.:
The nuclear IκB protein IκBNS selectively inhibits
lipopolysaccharide-induced IL-6 production in macrophages
of the colonic lamina propria. J. Immunol. 174, 3650-3657
(2005).
Kobayashi, M., Kweon, M., Kuwata, H., Kiyono, H., Takeda,
K., and Akira, S.: Toll-like receptor-dependent IL-12p40
production causes chronic enterocolitis in myeloid cell-specific
Stat3-deficient mice. J. Clin. Invest. 111, 1297-1308
(2003).
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T.,
Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda,
K., and Akira, S.: Role of adaptor TRIF in the MyD88-independent
Toll-like receptor signaling pathway. Science 301,
640-643 (2003).
Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S.,
Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita,
T., Takeda, K., and Akira, S.: Essential
role for TIRAP in activation of the signaling cascade shared
by TLR2 and TLR4. Nature 420, 324-329 (2002).
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S.,
Sanjo, H., Hoshino, K., Wagner, H., Takeda, K.,
and Akira, S.: A Toll-like receptor recognizes bacterial DNA.
Nature 408, 740-745 (2000).
Takeda, K., Takeuchi, O., Tsujimura, T.,
Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K.,
Terada, N., and Akira, S.: Limb and skin abnormalities in
mice lacking IKKα. Science 284, 313-316 (1999).
Takeda, K., Clausen, B., Kaisho, T., Tsujimura,
T., Terada, N., Forster, I., and Akira, S.: Enhanced Th1 activity
and development of chronic enterocolitis in mice devoid of
Stat3 in macrophages and neutrophils. Immunity 10,
39-49 (1999).
Takeda, K., Tsutsui, H., Yoshimoto, T., Adachi,
O., Yoshida, N., Kishimoto, T., Okamura, H., Nakanishi, K.,
and Akira, S.: Defective NK cell activity and Th1 response
in IL-18-deficient mice. Immunity, 8, 383-390 (1998).
Takeda, K., Tanaka,T., Shi, W., Matsumoto,
M., Minami, M., Kashiwamura, S., Nakanishi, K., Yoshida, N.,
Kishimoto, T., and Akira, S.: Essential role of Stat6 in IL-4
signalling. Nature 380, 627-630 (1996). |
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