6th The Awaji International Forum on Infection and Immunity  
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Nilabh Shastri, Ph.D.

Professor
Division of Immunology,
Department of Molecular and Cell Biology,
University of California, Berkeley
Education

1972 B.Sc. (Hons) Panjab Univ., Chandigarh, India (Chemistry)
1973 M.Sc. (Hons) Panjab Univ., Chandigarh, India (Organic Chemistry)
1980 Ph.D. All India Inst. Med. Sciences, New Delhi, India (Biochemistry)
Positions

1973-1980 Pre doctoral fellow, Dept. Biochemistry, All India Inst. Medical Sciences, New Delhi, India
1981-1984 Postdoctoral fellow, Dept Microbiology, University of California, Los Angeles
1984-1987 Senior Research fellow, Division Biology, California Institute of Technology, Pasadena
1987-1994 Assistant Professor, Dept. Molecular and Cell Biology, University of California, Berkeley, CA
1994-2000 Associate Professor, Dept. Molecular and Cell Biology, University of California, Berkeley, CA
2000 Visiting Professor, Dept. Cell Biology, Yale University, New Haven, CT
2000-present Professor, Dept. Molecular and Cell Biology, University of California, Berkeley, CA
Selected Publications (Total 103)

1. Mendoza,L., Paz,P., Zuberi,A.R., Christianson, G., Roopenian, D.C., Shastri,N. (1997). Minors held by majors. The H13 minor histocompatibility locus defined as a p/MHC class I complex. Immunity 7:461.
2. Shastri, N., T. Serwold and P. Paz (1998). Reading within the lines. Naturally processed peptides displayed by MHC class I molecules. Curr. Opin. Immunol. 10:137-144.
3. Malarkannan, S., Shih, P., Eden, P., Horng, T., Zuberi, A.R., Roopenian, D., Shastri, N. (1998). The molecular and functional characterization of a dominant H antigen, H60. J. Immunol 161:3501.
4. Zuberi, A.R., G.J. Christianson, L.M. Mendoza, N. Shastri and D.C. Roopenian (1998). Positional cloning and molecular characterization of an immunodominant cytotoxic determinant of the mouse H3 minor histocompatibility complex. Immunity 9:687-698.
5. Wong, S. F., J. Karttunen, C. Dumont, L. Wen, I. Visintin, I. Pilip, N. Shastri, E.G. Pamer and C. A. Janeway Jr. (1999). Insulin is the autoantigen recognised by highly diabetogenic CD8 T cell clones in the pathogenesis of type 1 diabetes in the NOD mouse. Nature Medicine 5:1026-1031.
6. Paz, P., N. Brouwenstijn, R. Perry and N. Shastri (1999). Discrete proteolytic intermediates in the MHC class I antigen processing pathway and MHC dependent peptide trimming in the endoplasmic reticulum. Immunity 11:241-251.
7. Malarkannan, S., T. Horng, P. Shih, S. Schwab and N. Shastri (1999). Presentation of out-of-frame peptide/MHC class I complexes by a novel translation initiation mechanism. Immunity 10:681-690
8. Campbell, D., T. Serwold and N. Shastri (2000). Bacterial proteins processed by macrophages in a TAP independent, cysteine protease dependent manner for presentation by MHC I. J. Immunol. 164:168-175.
9. Diefenbach, A., A.M. Jamieson, S.D. Liu, N. Shastri and D. Raulet (2000). Ligands for the murine NKG2D receptor: expression by tumor cells, activation of NK cells and macrophages. Nature Immunol. 1:119-126
10. Malarkannan, S., T. Horng, P. Eden, F. Gonzalez, P. Shih, N. Brouwenstijn, D. Roopenian and N. Shastri (2000). Differences that matter: Major cytotoxic T cell stimulating minor histocompatibility antigens. Immunity 13:333-344.
11. Mendoza, L. M., G. Villaflor, P. Eden, D. Roopenian and N. Shastri (2001). Distinguishing self from non-self. The antigenicity of the murine H47 locus is determined by a single subsitution in an unusual peptide of a novel gene. J. Immunol. 166:4438-4445.
12. E. Y. Choi, G. J. Christianson, T. J. Sproule, Y. Yoshimura, S. Malarkannan, N. Shastri, S. Joyce, D. C. Roopenian (2001). Quantitative analysis of the immune response to mouse non-MHC transplantation antigens in vivo: the H60 histocompatibility antigen dominates over all others J. Immunol. 166:4370-4379.
13. Serwold, T., S. Gaw and N. Shastri (2001). ER aminopeptidases generate a unique pool of peptides for presentation by MHC class I molecules. Nature Immunol. 2:644-651.
14. Brouwenstijn, N., T. Serwold and N. Shastri (2001). MHC class I molecules can direct proteolytic cleavage of antigenic precursors in the endoplasmic reticulum. Immunity 15:95-104
15. Shastri, N.. S. Schwab, T. Serwold (2002). Producing nature’s gene-chips. The generation of peptides for display by MHC class I molecules. Annu. Rev. Immunol. 20: 463-491.
16. Serwold, T., F. Gonzalez, J. Kim, R. Jacob and N. Shastri (2002). ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum. Nature 419:480-483.
17. Sahara, H. and N. Shastri (2003). Second class minors. Molecular identification of the autosomal H46 histocompatibility locus as a peptide presented by MHC class II molecules. J. Exp. Med.197:375-385
18. Schwab, S., K. Li, Chulho Kang and N. Shastri (2003). MHC I molecules constitutively present cryptic translation products. Science 301:1367-1371.
19. Kunisawa, J. and N. Shastri (2003). The hazards of living alone. Group II chaperonin TriC protects antigenic intermediates from degradation in the MHC class I antigen processing pathway Molecular Cell 12: 565-576.
20. Schwab, S., J. Shugart, T. Horng, S. Malarkannan, and N. Shastri (2004). Unanticipated antigens: Translational initiation at CUG with a leucine. PLoS Biology 2:e366.
21. Gubbels, M.-J., B. Striepen, N. Shastri, M. Turkoz, and E. A. Robey (2005). Class I MHC presentation of antigens that escape from the parasitophorous vacuole of Toxoplasma gondii. Infec. Immunity 73:703-11.
22. Shastri, N., S. Cardinaud, S. R. Schwab, T. Serwold and J. Kunisawa (2005). All the peptides that fit. The beginning, the middle, and the end of the MHC class I antigen processing pathway. Immunol. Rev. 207:31-41.
23. Kwon, Y. J., E. James, N. Shastri and J. M. Fréchet (2005). In vivo Targeting of Dendritic Cells for Activation of Cellular Immunity using Vaccine Carriers based on pH-responsive Microparticles Proc. Natl. Acad. Sci. (USA) 102(51):18264-8.
24. Hammer, G., F. Gonzalez, M. Champsaur, D. Cado and N. Shastri (2006). The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules. Nature Immunology 7:103-12.
25. Kunisawa, J. and N. Shastri (2006). Hsp90 chaperones large C-terminally extended proteolytic intermediates in the MHC I antigen processing pathway. Immunity 24:523-534.
26. Kanaseki, T., N. Blanchard, G. Hammer, F. Gonzalez and N. Shastri (2006). ERAAP synergizes with MHC I to generate the final cut in the antigenic peptide precursors in the endoplasmic reticulum. (Submitted)
 
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