| |
Nilabh Shastri, Ph.D.
Professor
Division of Immunology,
Department of Molecular and Cell Biology,
University of California, Berkeley |
 |
Education
| 1972 |
B.Sc. (Hons) |
Panjab Univ., Chandigarh, India (Chemistry) |
| 1973 |
M.Sc. (Hons) |
Panjab Univ., Chandigarh, India (Organic Chemistry) |
| 1980 |
Ph.D. |
All India Inst. Med. Sciences, New Delhi, India (Biochemistry) |
|
Positions
| 1973-1980 |
Pre doctoral fellow, Dept. Biochemistry, All
India Inst. Medical Sciences, New Delhi, India |
| 1981-1984 |
Postdoctoral fellow, Dept Microbiology, University of California,
Los Angeles |
| 1984-1987 |
Senior Research fellow, Division Biology, California Institute
of Technology, Pasadena |
| 1987-1994 |
Assistant Professor, Dept. Molecular and Cell Biology, University
of California, Berkeley, CA |
| 1994-2000 |
Associate Professor, Dept. Molecular and Cell Biology, University
of California, Berkeley, CA |
| 2000 |
Visiting Professor, Dept. Cell Biology, Yale University,
New Haven, CT |
| 2000-present |
Professor, Dept. Molecular and Cell Biology, University
of California, Berkeley, CA |
|
Selected Publications (Total 103)
| 1. |
Mendoza,L., Paz,P., Zuberi,A.R., Christianson,
G., Roopenian, D.C., Shastri,N.
(1997). Minors held by majors. The H13 minor histocompatibility
locus defined as a p/MHC class I complex. Immunity
7:461. |
| 2. |
Shastri, N.,
T. Serwold and P. Paz (1998). Reading within the lines. Naturally
processed peptides displayed by MHC class I molecules. Curr.
Opin. Immunol. 10:137-144. |
| 3. |
Malarkannan, S., Shih, P., Eden, P., Horng, T., Zuberi,
A.R., Roopenian, D., Shastri, N.
(1998). The molecular and functional characterization of a
dominant H antigen, H60. J. Immunol
161:3501. |
| 4. |
Zuberi, A.R., G.J. Christianson, L.M. Mendoza, N.
Shastri and D.C. Roopenian (1998). Positional
cloning and molecular characterization of an immunodominant
cytotoxic determinant of the mouse H3 minor histocompatibility
complex. Immunity 9:687-698. |
| 5. |
Wong, S. F., J. Karttunen, C. Dumont, L. Wen, I. Visintin,
I. Pilip, N. Shastri, E.G. Pamer and C. A.
Janeway Jr. (1999). Insulin is the autoantigen recognised
by highly diabetogenic CD8 T cell clones in the pathogenesis
of type 1 diabetes in the NOD mouse. Nature Medicine
5:1026-1031. |
| 6. |
Paz, P., N. Brouwenstijn, R. Perry and N. Shastri
(1999). Discrete proteolytic intermediates in the MHC class
I antigen processing pathway and MHC dependent peptide trimming
in the endoplasmic reticulum. Immunity
11:241-251. |
| 7. |
Malarkannan, S., T. Horng, P. Shih, S. Schwab and N.
Shastri (1999). Presentation of out-of-frame peptide/MHC
class I complexes by a novel translation initiation mechanism.
Immunity 10:681-690 |
| 8. |
Campbell, D., T. Serwold and N. Shastri
(2000). Bacterial proteins processed by macrophages in a TAP
independent, cysteine protease dependent manner for presentation
by MHC I. J. Immunol. 164:168-175. |
| 9. |
Diefenbach, A., A.M. Jamieson, S.D. Liu, N. Shastri
and D. Raulet (2000). Ligands for the murine NKG2D receptor:
expression by tumor cells, activation of NK cells and macrophages.
Nature Immunol. 1:119-126 |
| 10. |
Malarkannan, S., T. Horng, P. Eden, F. Gonzalez, P. Shih,
N. Brouwenstijn, D. Roopenian and N. Shastri
(2000). Differences that matter: Major cytotoxic T cell stimulating
minor histocompatibility antigens. Immunity
13:333-344. |
| 11. |
Mendoza, L. M., G. Villaflor, P. Eden, D. Roopenian and
N. Shastri (2001). Distinguishing self from
non-self. The antigenicity of the murine H47 locus is determined
by a single subsitution in an unusual peptide of a novel gene.
J. Immunol. 166:4438-4445. |
| 12. |
E. Y. Choi, G. J. Christianson, T. J. Sproule, Y. Yoshimura,
S. Malarkannan, N. Shastri, S. Joyce, D.
C. Roopenian (2001). Quantitative analysis of the immune response
to mouse non-MHC transplantation antigens in vivo: the H60
histocompatibility antigen dominates over all others J.
Immunol. 166:4370-4379. |
| 13. |
Serwold, T., S. Gaw and N. Shastri (2001). ER aminopeptidases
generate a unique pool of peptides for presentation by MHC
class I molecules. Nature Immunol. 2:644-651. |
| 14. |
Brouwenstijn, N., T. Serwold and N. Shastri
(2001). MHC class I molecules can direct proteolytic cleavage
of antigenic precursors in the endoplasmic reticulum. Immunity
15:95-104 |
| 15. |
Shastri, N.. S. Schwab, T. Serwold (2002).
Producing nature’s gene-chips. The generation of peptides
for display by MHC class I molecules. Annu. Rev.
Immunol. 20: 463-491. |
| 16. |
Serwold, T., F. Gonzalez, J. Kim, R. Jacob and N.
Shastri (2002). ERAAP customizes peptides for MHC
class I molecules in the endoplasmic reticulum. Nature
419:480-483. |
| 17. |
Sahara, H. and N. Shastri (2003). Second
class minors. Molecular identification of the autosomal H46
histocompatibility locus as a peptide presented by MHC class
II molecules. J. Exp. Med.197:375-385 |
| 18. |
Schwab, S., K. Li, Chulho Kang and N. Shastri
(2003). MHC I molecules constitutively present cryptic translation
products. Science 301:1367-1371. |
| 19. |
Kunisawa, J. and N. Shastri (2003). The
hazards of living alone. Group II chaperonin TriC protects
antigenic intermediates from degradation in the MHC class
I antigen processing pathway Molecular Cell 12:
565-576. |
| 20. |
Schwab, S., J. Shugart, T. Horng, S. Malarkannan, and N.
Shastri (2004). Unanticipated antigens: Translational
initiation at CUG with a leucine. PLoS Biology
2:e366. |
| 21. |
Gubbels, M.-J., B. Striepen, N. Shastri,
M. Turkoz, and E. A. Robey (2005). Class I MHC presentation
of antigens that escape from the parasitophorous vacuole of
Toxoplasma gondii. Infec. Immunity
73:703-11. |
| 22. |
Shastri, N., S. Cardinaud,
S. R. Schwab, T. Serwold and J. Kunisawa (2005). All the peptides
that fit. The beginning, the middle, and the end of the MHC
class I antigen processing pathway. Immunol. Rev.
207:31-41. |
| 23. |
Kwon, Y. J., E. James, N. Shastri and J.
M. Fréchet (2005). In vivo Targeting of Dendritic Cells for
Activation of Cellular Immunity using Vaccine Carriers based
on pH-responsive Microparticles Proc. Natl. Acad.
Sci. (USA) 102(51):18264-8. |
| 24. |
Hammer, G., F. Gonzalez, M. Champsaur, D. Cado and N.
Shastri (2006). The aminopeptidase ERAAP shapes the
peptide repertoire displayed by major histocompatibility complex
class I molecules. Nature Immunology
7:103-12. |
| 25. |
Kunisawa, J. and N. Shastri (2006). Hsp90
chaperones large C-terminally extended proteolytic intermediates
in the MHC I antigen processing pathway. Immunity
24:523-534. |
| 26. |
Kanaseki, T., N. Blanchard, G. Hammer, F. Gonzalez and N. Shastri (2006). ERAAP synergizes with MHC I to generate the
final cut in the antigenic peptide precursors in the endoplasmic
reticulum. (Submitted) |
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