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Kensuke Miyake, M.D., Ph.D.
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Education:
| March 1984 |
Graduated from Okayama University Medical School |
| March 1988 |
Finished the doctor course (Dr. Toshiyuki Hamaoka) at Osaka
University Medical School, receiving the degree of the Doctor
of Medical Science. |
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Occupation:
| April 1988 |
Research associate in the Immunobiology and
cancer program, Oklahoma Medical Research foundation
(Dr. Paul W. Kincade) |
| August 1990 |
Assistant professor in the Department of Immunology, Saga
Medical School |
| August 1993 |
Associate professor in the Department of Immunology, Saga
Medical School |
| May 2001 |
Professor, Division of Infectious Genetics, Department of
Microbiology and Immunology, The Institute of Medical Science,
The University of Tokyo |
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Selected Publications
| 1. |
Miyake, K.,
Y. Yamashita, M. Ogata, T. Sudo, and M. Kimoto. 1995. RP105,
a novel B cell surface molecule implicated in B cell activation,
is a member of the leucine-rich repeat protein family. J.
Immunol. 154: 3333-3340. |
| 2. |
Miyake, K., R. Shimazu, J. Kondo, T. Niki,
S. Akashi, H. Ogata, Y. Yamashita, Y. Miura, and M. Kimoto.
1998. Mouse MD-1, a molecule that is physically associated
with RP105 and positively regulates its expression. J.
Immunol. 161: 1348-1353. |
| 3. |
Shimazu, R., S. Akashi, H. Ogata, Y. Nagai, K. Fukudome,
K. Miyake, and M. Kimoto. 1999. MD-2, a molecule that confers
lipopolysaccharide responsiveness on Toll-like receptor 4.
J. Exp. Med. 189: 1777-1782. |
| 4. |
Ogata, H., I. Su, K. Miyake, Y. Nagai, S. Akashi, I. Mecklenbräuker,
K. Rajewsky, M. Kimoto, and A. Tarakhovsky. 2000. The Toll-like
Receptor Protein RP105 Regulates Lipopolysaccharide Signaling
in B Cells. J. Exp. Med. 192: 23-30. |
| 5. |
Nagai, Y., S. Akashi, M. Nagafuku, M. Ogata, Y. Iwakura,
S. Akira, T. Kitamura, A. Kosugi, M. Kimoto, and K. Miyake.
2002. Essential role of MD-1 in lipopolysaccharide responsiveness
and Toll-like receptor 4 distribution. Nat. Immunol.
3:667-672 |
| 6. |
Miyake, K. Innate recognition of lipopolysaccharide by CD14
and toll-like receptor 4-MD-2: unique roles for MD-2. Int
Immunopharmacol. 2003 1:119-128 |
| 7. |
S Akashi, S Saitoh, Y Wakabayashi, T Kikuchi, N Takamura,
Y Nagai, Y Kusumoto, K Fukase, S Kusumoto, Y Adachi, A Kosugi,
K Miyake. Lipopolysaccharide Interaction with Cell Surface
Toll-like Receptor 4-MD-2: Higher Affinity than that with
MD-2 or CD14. J. Exp. Med. 2003, 198: 1035-1042. |
| 8. |
Miyake K. Endotoxin recognition molecules, Toll-like receptor
4-MD-2. Semin Immunol. 2004 16:11-16. |
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