6th The Awaji International Forum on Infection and Immunity  
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Kensuke Miyake, M.D., Ph.D.

March 1984 Graduated from Okayama University Medical School
March 1988 Finished the doctor course (Dr. Toshiyuki Hamaoka) at Osaka University Medical School, receiving the degree of the Doctor of Medical Science.


April 1988 Research associate in the Immunobiology and cancer program, Oklahoma Medical Research foundation
(Dr. Paul W. Kincade)
August 1990 Assistant professor in the Department of Immunology, Saga Medical School
August 1993 Associate professor in the Department of Immunology, Saga Medical School
May 2001 Professor, Division of Infectious Genetics, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo

Selected Publications

1. Miyake, K., Y. Yamashita, M. Ogata, T. Sudo, and M. Kimoto. 1995. RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family. J. Immunol. 154: 3333-3340.
2. Miyake, K., R. Shimazu, J. Kondo, T. Niki, S. Akashi, H. Ogata, Y. Yamashita, Y. Miura, and M. Kimoto. 1998. Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression. J. Immunol. 161: 1348-1353.
3. Shimazu, R., S. Akashi, H. Ogata, Y. Nagai, K. Fukudome, K. Miyake, and M. Kimoto. 1999. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189: 1777-1782.
4. Ogata, H., I. Su, K. Miyake, Y. Nagai, S. Akashi, I. Mecklenbräuker, K. Rajewsky, M. Kimoto, and A. Tarakhovsky. 2000. The Toll-like Receptor Protein RP105 Regulates Lipopolysaccharide Signaling in B Cells. J. Exp. Med. 192: 23-30.
5. Nagai, Y., S. Akashi, M. Nagafuku, M. Ogata, Y. Iwakura, S. Akira, T. Kitamura, A. Kosugi, M. Kimoto, and K. Miyake. 2002. Essential role of MD-1 in lipopolysaccharide responsiveness and Toll-like receptor 4 distribution. Nat. Immunol. 3:667-672
6. Miyake, K. Innate recognition of lipopolysaccharide by CD14 and toll-like receptor 4-MD-2: unique roles for MD-2. Int Immunopharmacol. 2003 1:119-128
7. S Akashi, S Saitoh, Y Wakabayashi, T Kikuchi, N Takamura, Y Nagai, Y Kusumoto, K Fukase, S Kusumoto, Y Adachi, A Kosugi, K Miyake. Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2: Higher Affinity than that with MD-2 or CD14. J. Exp. Med. 2003, 198: 1035-1042.
8. Miyake K. Endotoxin recognition molecules, Toll-like receptor 4-MD-2. Semin Immunol. 2004 16:11-16.
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