6th The Awaji International Forum on Infection and Immunity  
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Mitchell Kronenberg, Ph.D.

Scientific Director and President
La Jolla Institute for Allergy & Immunology

1973 B.S. Columbia University, New York, NY
1974-1983 Ph.D. California Institute of Technology, Pasadena, CA

Professional Experience:

1983-1986 Postdoc California Institute of Technology, Pasadena, CA
1986-1992 Assistant Professor, Microbiology & Immunology, UCLA
1992-1997 Associate Professor of Microbiology & Immunology, UCLA
1997 Professor of Microbiology & Immunology & Medicine, Division of Digestive Diseases, UCLA
1997-present Division Head and Member, Division of Developmental Immunology, La Jolla Institute for Allergy & Immunology, San Diego, CA; Adjunct Professor of Biology, U. C. San Diego
2003-present Scientific Director and President, La Jolla Institute for Allergy & Immunology
Relevant Publications (202 papers total, selected peer reviewed papers since 1995)

1. Holcombe, H.R., Castaño, A.R., Cheroutre, H., Teitell, M., Maher, J.K., Peterson, P.A., and Kronenberg, M. Nonclassical behavior of the thymus leukemia antigen: peptide transporter independent expression of a nonclassical class I molecule. J. Exp. Med. 181:1433-1444, 1995.
2. Penninger, J.M., Wen, T., Timms, E., Potter, J., Wallace, V.A., Ferrick, D., Sydora, B., Kronenberg, M., and Mak, T.W. Spontaneous resistance to acute T cell leukemias in TCRVγ1.1Jγ4Cγ4 transgenic mice. Nature 375:241-244, 1995.
3. Castaño, A.R., Tangri, S., Miller, J.E.W., Holcombe, H.R., Jackson, M.R., Huse, W.D., Kronenberg, M., and Peterson, P.A. Peptide binding and presenting properties of mouse CD1. Science 269:223-226, 1995.
4. Seiling, P.A., Chatterjee, D., Porcelli, S.A., Prigozy, T.I., Mazzaccaro, R.J., Soriano, T., Bloom, B.R., Brenner, M.B., Kronenberg, M., Brennan, P.J., and Modlin, R.L. CD1-restricted T-cell recognition of microbial lipoglycan antigens. Science 269:227-230, 1995.
5. Prigozy, T.I., Sieling, P.A., Clemens, D., Behar, S.M., Porcelli, S.A., Brenner, M.B., Stewart, P.L., Modlin, R.L., and Kronenberg, M. CD1-mediated presentation of a lipoglycan to T cells requires uptake by the mannose receptor and transport to a late endosome. Immunity, 6: 187-197, 1997.
6. Hagenbaugh, A., Sharma, S., Dubinett, S.M., Wei, S.H.-Y., Aranda, R., Cheroutre, H., Fowell, D., Binder, S., Tsao, B., Locksley, R.M., Moore, K.W., and Kronenberg, M. Altered immune responses in IL-10 transgenic mice. J. Exp. Med, 185: 2101-2110, 1997.
7. Ernst, W. A., Maher, J., Cho, S., Niazi, K., Chatterjee, D., Moody, D.B., Besra, G.S., Watanabe, Y., Jensen, P.E., Porcelli, S.A., Kronenberg, M., and Modlin, R.L. Molecular interaction of CD1b with lipoglycan antigens. Immunity, 8: 331-340, 1998.
8. Cruz, D., Sydora, B.C., Hetzel, K., Yakoub, G., Kronenberg, M., and Cheroutre, H. An opposite pattern of selection of a single T cell antigen receptor in the thymus and among intraepithelial lymphocytes. J. Exp. Med., 188: 255-265, 1998.
9. Brossay, L., Chioda, M., Burdin, N., Koezuka, Y., Casorati, G., Dellabona, P., and Kronenberg, M. CD1d mediated recognition of a α-Galactosylceramide by NK T cells is highly conserved through mammalian evolution. J. Exp. Med. 188: 1521-1528, 1998.
10. Naidenko, O., Maher, J.K., Ernst, W., Sakai, T., Modlin, R.L., and Kronenberg, M. Binding and antigen presentation of ceramide containing glycolipids by soluble mouse and human CD1d molecules. J. Exp. Med., 190:1069-1080, 1999.
11. Matsuda, J. L., Naidenko O. V., Gapin, L., Nakayama, T., Taniguchi, M., Wang C.-R., Koezuka, Y., and Kronenberg, M. Tracking the response of NK T cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med., 192:741-754, 2000.
12. Shamshiev, A., Donda, A., Prigozy, T. I., Mori, L., Chigorno, V., Benedict, C.A., Kappos, L., Sonnino, S., Kronenberg, M., and De Libero, G. The αβ T cell response to self glycosphingolipids reveals a requirement for complex oligosaccharides and a novel mechanism of carbohydrate antigen recognition. Immunity, 13: 255-264, 2000.
13. Prigozy, T. I., Naidenko, O., Qasba, P., Elewaut, D., Brossay, L., Khurana, A., Natori, T., Koezuka, Y., Kulkarni, A., and Kronenberg, M. Processing of carbohydrates for glycolipid antigen presentation by CD1d molecules. Science, 291: 664-7, 2001.
14. Dalwadi, H., Wei, B., Kronenberg, M., Sutton, C.L., and Braun, J. The Crohn's disease associated bacterial protein I2 is a novel enteric T cell superantigen. Immunity, 15: 149-158, 2001.
15. Hong, S., Wilson, M.T., Serizawa, I., Wu, L., Singh, N., Naidenko, O.V., Miura, T., Haba, T., Scherer, D.C., Wei, J., Kronenberg, M., Koezuka, Y., & Van Kaer, L. The natural killer T cell ligand α-galactosyl ceramide prevents autoimmune diabetes in NOD mice. Nat. Med., 7:1052-6, 2001.
16. Gapin, L., Matsuda, J., Surh, C., and Kronenberg, M. NKT cells derive from double positive thymocytes positively selected by CD1d molecules, Nature Immunology, 2:971-978, 2001.
17. Matsuda, J.L., Gapin, L., Fazilleau, N., Warren, K., Naidenko, O.V., and Kronenberg, M. Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T-cell receptor β repertoire and small clone size. Proc. Natl. Acad. Sci. USA, 98:12636-12641, 2001.
18. Leishman, A., Naidenko, O.V., Attinger, A., Koning, F., Lena, C., Xiong, Y., Chang, H.-C., Reinherz, E.L., Kronenberg, M., and Cheroutre, H. T Cell Responses Modulated Through Interaction Between CD8αα& Nonclassical MHC class I molecule, TL. Science 294:1936-1939, 2001.
19. De Winter, H., Elewaut, D., Turovskaya, O., Huflejt, M., Shimeld, C., Hagenbaugh, A., Binder, S., Takahashi, I., Kronenberg, M., & Cheroutre, H. Regulation of Mucosal Immune Responses by Recombinant Interleukin 10 Produced by Intestinal Epithelial Cells in Mice. Gastroenterol 122: 1829-41, 2002.
20. Matsuda, J.L., Gapin, L., Sidobre, S., Kieper, W.C., Tan, J.T., Ceredig, R., Surh, C.D., and Kronenberg, M. Homeostasis of Vα14i NKT cells. Nature Immunology, 3:966-974, 2002.
21. Akbari, O., Meyer, E., Stock, P., Kronenberg, M., Sidobre, S., Nakayama, T., Taniguchi, M., Grussby, M., DeKruyff, R.H. & Umetsu, D.T. Critical role of NKT cells producing IL-4 and IL-13 in the development of allergen induced airway hyperreactivity. Nature Medicine, 9: 582-588, 2003.
22. Elewaut, D., Shaikh, R.B., Hammond, K.J.L., DeWinter, H., Leishman, A.J., Sidobre, S., Turovskaya, O., Prigozy, T.I., Ma, L., Banks, T., Lo, D., Ware, C.F., Cheroutre, H., and Kronenberg, M. NIK-dependent RelB Activation defines a unique signaling pathway for the development of Vα14i NKT Cells. J. Exp. Med. 197: 1623-1633, 2003.
23. Matsuda, J.L., Gapin, L., Baron, J.L., Sidobre, S., Stetson, D.B., Mohrs, M., Locksley, R.M. and Kronenberg, M. Mouse Vα14i NKT cells are resistant to cytokine polarization in vivo. Proc. Natl. Acad. Sci. USA. 100: 8395-8400, 2003.
24. Sidobre S, Hammond KJ, Benazet-Sidobre L, Maltsev SD, Richardson SK, Ndonye RM, Howell AR, Sakai T, Besra GS, Porcelli SA, Kronenberg M. The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition. Proc. Natl. Acad. Sci. USA 101:12254-9, 2004.
25. Kinjo, Y., Wu, D., Kim, G., Xing, G.-W., Poles, M.A., Ho, D.D., Tsuji, M. Kawahara, K., Wong, C.-H., Kronenberg, M. Recognition of bacterial glycosphingolipids by natural killer T cells. Nature, 434: 520-5, 2005
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