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Mitchell Kronenberg, Ph.D.
Scientific Director and President
La Jolla Institute for Allergy & Immunology |
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Education:
| 1973 |
B.S. |
Columbia University, New York, NY |
| 1974-1983 |
Ph.D. |
California Institute of Technology, Pasadena, CA |
|
Professional Experience:
| 1983-1986 |
Postdoc California Institute of Technology,
Pasadena, CA |
| 1986-1992 |
Assistant Professor, Microbiology & Immunology, UCLA |
| 1992-1997 |
Associate Professor of Microbiology & Immunology, UCLA |
| 1997 |
Professor of Microbiology & Immunology & Medicine,
Division of Digestive Diseases, UCLA |
| 1997-present |
Division Head and Member, Division of Developmental Immunology,
La Jolla Institute for Allergy & Immunology, San Diego,
CA; Adjunct Professor of Biology, U. C. San Diego |
| 2003-present |
Scientific Director and President, La Jolla Institute for
Allergy & Immunology |
|
Relevant Publications (202 papers
total, selected peer reviewed papers since 1995)
| 1. |
Holcombe, H.R., Castaño, A.R., Cheroutre,
H., Teitell, M., Maher, J.K., Peterson, P.A., and Kronenberg,
M. Nonclassical behavior of the thymus leukemia antigen:
peptide transporter independent expression of a nonclassical
class I molecule. J. Exp. Med. 181:1433-1444, 1995. |
| 2. |
Penninger, J.M., Wen, T., Timms, E., Potter, J., Wallace,
V.A., Ferrick, D., Sydora, B., Kronenberg, M.,
and Mak, T.W. Spontaneous resistance to acute T cell leukemias
in TCRVγ1.1Jγ4Cγ4 transgenic mice. Nature
375:241-244, 1995. |
| 3. |
Castaño, A.R., Tangri, S., Miller, J.E.W., Holcombe,
H.R., Jackson, M.R., Huse, W.D., Kronenberg, M.,
and Peterson, P.A. Peptide binding and presenting properties
of mouse CD1. Science 269:223-226, 1995. |
| 4. |
Seiling, P.A., Chatterjee, D., Porcelli, S.A., Prigozy,
T.I., Mazzaccaro, R.J., Soriano, T., Bloom, B.R., Brenner,
M.B., Kronenberg, M., Brennan, P.J., and
Modlin, R.L. CD1-restricted T-cell recognition of microbial
lipoglycan antigens. Science 269:227-230, 1995. |
| 5. |
Prigozy, T.I., Sieling, P.A., Clemens, D., Behar, S.M.,
Porcelli, S.A., Brenner, M.B., Stewart, P.L., Modlin, R.L.,
and Kronenberg, M. CD1-mediated presentation
of a lipoglycan to T cells requires uptake by the mannose
receptor and transport to a late endosome. Immunity,
6: 187-197, 1997. |
| 6. |
Hagenbaugh, A., Sharma, S., Dubinett, S.M., Wei, S.H.-Y.,
Aranda, R., Cheroutre, H., Fowell, D., Binder, S., Tsao, B.,
Locksley, R.M., Moore, K.W., and Kronenberg, M.
Altered immune responses in IL-10 transgenic mice. J.
Exp. Med, 185: 2101-2110, 1997. |
| 7. |
Ernst, W. A., Maher, J., Cho, S., Niazi, K., Chatterjee,
D., Moody, D.B., Besra, G.S., Watanabe, Y., Jensen, P.E.,
Porcelli, S.A., Kronenberg, M., and Modlin,
R.L. Molecular interaction of CD1b with lipoglycan antigens.
Immunity, 8: 331-340, 1998. |
| 8. |
Cruz, D., Sydora, B.C., Hetzel, K., Yakoub, G., Kronenberg,
M., and Cheroutre, H. An opposite pattern of selection
of a single T cell antigen receptor in the thymus and among
intraepithelial lymphocytes. J. Exp. Med., 188: 255-265,
1998. |
| 9. |
Brossay, L., Chioda, M., Burdin, N., Koezuka, Y., Casorati,
G., Dellabona, P., and Kronenberg, M. CD1d
mediated recognition of a α-Galactosylceramide by NK T cells
is highly conserved through mammalian evolution. J. Exp.
Med. 188: 1521-1528, 1998. |
| 10. |
Naidenko, O., Maher, J.K., Ernst, W., Sakai, T., Modlin,
R.L., and Kronenberg, M. Binding and antigen
presentation of ceramide containing glycolipids by soluble
mouse and human CD1d molecules. J. Exp. Med., 190:1069-1080,
1999. |
| 11. |
Matsuda, J. L., Naidenko O. V., Gapin, L., Nakayama, T.,
Taniguchi, M., Wang C.-R., Koezuka, Y., and Kronenberg,
M. Tracking the response of NK T cells to a glycolipid
antigen using CD1d tetramers. J. Exp. Med., 192:741-754,
2000. |
| 12. |
Shamshiev, A., Donda, A., Prigozy, T. I., Mori, L., Chigorno,
V., Benedict, C.A., Kappos, L., Sonnino, S., Kronenberg,
M., and De Libero, G. The αβ T cell response to self
glycosphingolipids reveals a requirement for complex oligosaccharides
and a novel mechanism of carbohydrate antigen recognition.
Immunity, 13: 255-264, 2000. |
| 13. |
Prigozy, T. I., Naidenko, O., Qasba, P., Elewaut, D., Brossay,
L., Khurana, A., Natori, T., Koezuka, Y., Kulkarni, A., and
Kronenberg, M. Processing of carbohydrates
for glycolipid antigen presentation by CD1d molecules. Science,
291: 664-7, 2001. |
| 14. |
Dalwadi, H., Wei, B., Kronenberg, M., Sutton,
C.L., and Braun, J. The Crohn's disease associated bacterial
protein I2 is a novel enteric T cell superantigen. Immunity,
15: 149-158, 2001. |
| 15. |
Hong, S., Wilson, M.T., Serizawa, I., Wu, L., Singh, N.,
Naidenko, O.V., Miura, T., Haba, T., Scherer, D.C., Wei, J.,
Kronenberg, M., Koezuka, Y., & Van Kaer,
L. The natural killer T cell ligand α-galactosyl ceramide
prevents autoimmune diabetes in NOD mice. Nat. Med.,
7:1052-6, 2001. |
| 16. |
Gapin, L., Matsuda, J., Surh, C., and Kronenberg,
M. NKT cells derive from double positive thymocytes
positively selected by CD1d molecules, Nature Immunology,
2:971-978, 2001. |
| 17. |
Matsuda, J.L., Gapin, L., Fazilleau, N., Warren, K., Naidenko,
O.V., and Kronenberg, M. Natural killer T
cells reactive to a single glycolipid exhibit a highly diverse
T-cell receptor β repertoire and small clone size. Proc.
Natl. Acad. Sci. USA, 98:12636-12641, 2001. |
| 18. |
Leishman, A., Naidenko, O.V., Attinger, A., Koning, F.,
Lena, C., Xiong, Y., Chang, H.-C., Reinherz, E.L., Kronenberg,
M., and Cheroutre, H. T Cell Responses Modulated
Through Interaction Between CD8αα& Nonclassical
MHC class I molecule, TL. Science 294:1936-1939,
2001. |
| 19. |
De Winter, H., Elewaut, D., Turovskaya, O., Huflejt, M.,
Shimeld, C., Hagenbaugh, A., Binder, S., Takahashi, I., Kronenberg,
M., & Cheroutre, H. Regulation of Mucosal Immune
Responses by Recombinant Interleukin 10 Produced by Intestinal
Epithelial Cells in Mice. Gastroenterol 122: 1829-41,
2002. |
| 20. |
Matsuda, J.L., Gapin, L., Sidobre, S., Kieper, W.C., Tan,
J.T., Ceredig, R., Surh, C.D., and Kronenberg, M.
Homeostasis of Vα14i NKT cells. Nature Immunology,
3:966-974, 2002. |
| 21. |
Akbari, O., Meyer, E., Stock, P., Kronenberg, M.,
Sidobre, S., Nakayama, T., Taniguchi, M., Grussby, M., DeKruyff,
R.H. & Umetsu, D.T. Critical role of NKT cells producing
IL-4 and IL-13 in the development of allergen induced airway
hyperreactivity. Nature Medicine, 9: 582-588, 2003.
|
| 22. |
Elewaut, D., Shaikh, R.B., Hammond, K.J.L., DeWinter, H.,
Leishman, A.J., Sidobre, S., Turovskaya, O., Prigozy, T.I.,
Ma, L., Banks, T., Lo, D., Ware, C.F., Cheroutre, H., and
Kronenberg, M. NIK-dependent RelB Activation
defines a unique signaling pathway for the development of
Vα14i NKT Cells. J. Exp. Med. 197: 1623-1633,
2003. |
| 23. |
Matsuda, J.L., Gapin, L., Baron, J.L., Sidobre, S., Stetson,
D.B., Mohrs, M., Locksley, R.M. and Kronenberg, M.
Mouse Vα14i NKT cells are resistant to cytokine polarization
in vivo. Proc. Natl. Acad. Sci. USA. 100: 8395-8400,
2003. |
| 24. |
Sidobre S, Hammond KJ, Benazet-Sidobre L, Maltsev SD, Richardson
SK, Ndonye RM, Howell AR, Sakai T, Besra GS, Porcelli SA,
Kronenberg M. The T cell antigen receptor
expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid
antigen recognition. Proc. Natl. Acad. Sci. USA 101:12254-9,
2004. |
| 25. |
Kinjo, Y., Wu, D., Kim, G., Xing, G.-W., Poles, M.A., Ho,
D.D., Tsuji, M. Kawahara, K., Wong, C.-H., Kronenberg,
M. Recognition of bacterial glycosphingolipids by
natural killer T cells. Nature, 434: 520-5, 2005 |
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