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Hiroshi Kiyono,D.D.S., Ph.D.
Professor
Division of Mucosal Immunology
Department of Microbiology and Immunology
Institute of Medical Science
The University of Tokyo |
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Education
| 1972 |
D.D.S. |
Nihon University., School of Dentistry at Matsuudo
Matsudo, Chiba, Japan |
| 1983 |
Ph.D. |
Department of Pathology, Graduate School,University of Alabama
at Birmingham, Medical Center, Birmingham, Alabama |
|
Positions
| 1984-1987 |
Research and Clinical Assistant Professor, Department
of Oral Biology University of Alabama at Birmingha, Medical
Center |
| 1986-1987 |
Visiting Senior Scientist, Infectious Disease Research Unit,
Molecular Biology Section(with Dr. Thomas F. Meyer) Max-Planck
Institute For Biology Tubingen, Federal Republic of Germany |
| 1988-1990 |
Associate Professor, Departments of Oral Biology and Microbiology,
University of Alabama at Birmingham, Medical Center |
| 1991-2003 |
Professor, Departments of Oral Biology and Microbiology,University
of Alabama at Birmingham, Medical Center |
| 1992-1996 |
Co-Director, Immunobiology Vaccine Center, University of
Alabama at Birmingham, Medical Center, Birmingham, Alabama |
| 1994-2003 |
Professor and Chairman, Department of Mucosal Immunology,
Research Institute for Microbial Diseases, Osaka University,
Osaka, Japan |
| 2004-present |
Adjunct Professor, Immunobiology Vaccine Center, University
of Alabama at Birmingham,
Medical Center, Birmingham, Alabama |
| 2000-present |
Professor and Director, Division of Mucosal Immunology,
Department of Microbiology and Immunology,
The Institute of Medical Science, The University of Tokyo,Tokyo,
Japan |
| 2005-present |
Professor and Chairman, Department of Microbiology and Immunology,
The Institute of Medical Science, The University of Tokyo,
Tokyo, Japan |
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Selected Publications
| 1. |
Takagi, H., Hiroi, T., Yang, L., Tada, Y., Yuki,
Y., Takamura, K., Ishimitsu, R., Kawauchi, H., Kiyono,
H., and Takaiwa, F., 2005. A rice-based
edible vaccine expressing multiple T cell epitopes induces
oral tolerance for inhibition of Th2-mediated IgE responses.
Proc Natl Acad Sci USA 102 : 17525-17530 |
| 2. |
Hino A., Fukuyama S., Kataoka K., Kweon MN., Fujihashi K.,
and Kiyono, H.,
2005. Nasal IL-12p70 DNA prevents and treats intestinal allergic
diarrhea. J Immunol. 174 : 7423-32 |
| 3. |
Kai, Y., Takahashi, I., Ishikawa, H., Hiroi, T., Mizushima,
T., Matsuda, C., Kishi, D., Hamada, H., Tamagawa, H., Ito,
T., Yoshizaki, K., Kishimoto, T., Matsuda, H., and Kiyono,
H., 2005. Colitis in mice lacking the common
cytokine receptor gamma chain is mediated by IL-6-producing
CD4+ T cells. Gastroenterology 128 : 922-934 |
| 4. |
Kiyono, H., and Fukuyama,
S. 2004. NALT-versus Peyer’s-patch-mediated mucosal immunity.
2004. Nature Rev. Immunol. 4 : 699-710 |
| 5. |
Jang, M-H., Kweon, M-N., Iwatani, K., Yamamoto, M., Terahara,
K., Sasakawa, G., Suzuki, T., Nochi, T., Yokota, Y., Hiroi,
T., Tamagawa, H., Iijima, H., Kunisawa, J., Yuki, Y., and
Kiyono, H. 2004. Intestinal
Villous M Cells: A new antigen entry site in the mucosal epithelium.
Proc. Natl. Asso. Sci. 101 : 6110-6115 |
| 6. |
Shikina, T., Hiroi, T., Iwatani, K., Jan, M-H., Fukuyama,
S., Tamura, M., Kubo, T., Ishikawa, H. and Kiyono,
H. 2004. IgA class switch occurs in the organized
nasopharynx and gut-associated lymphoid tissue, but not in
the diffuse lamina proposal of airways and gut. J. Immunol.
172 : 6259-6264 |
| 7. |
6. Park, E-J., Takahashi, I., Ikeda J., Kawahara, K., Okamoto,
T., Kweon, M-N., Fukuyama, S., Groh, V., Spies, T., Obata,
Y., Miyazaki, J. and Kiyono, H. 2003. Clonal
expansion of double-positive (DP) IELs by MICA expressed in
mouse small intestinal epithelium. J. Immunol. 171
: 4131-4139 |
| 8. |
Okuda, Y., Takahashi, I., Kim, J-K., Ohta,N., Iwatani, K.,
Kai, Y., Tamagawa, H., Hiroi, T., Kweon, M-N., Kawano, S.,
Sasaki, Y., Hori, M., Takeda, K., Akira, S. and Kiyono,
H. 2003. Development of colitis in STAT6-deficient
TCRα-/-mice: A potential of STAT6-independent IL-4 signaling
for the generation of Th2-biased pathologic CD4+ββＴcells.
Am. J. Pathol. 162 : 263-271 |
| 9. |
Fukuyama, S., Hiroi, T., Yokota, Y., Rennert, P.D., Yanagita,
M., Kinoshita, N., Terawaki, S., Shikina, T., Yamamoto, M.,
Kurono, Y. and Kiyono, H. 2002. NALT organogenesisn
is independent of the IL-7R, LT 12/LTR and NIK signaling
pathways but does require the Id2 gene and CD3- CD4+CD45+
cells. Immunity 17 : 31-40 |
| 10. |
Ohta, N., Hiroi, T., Kweon, M-N., Kinoshita, N., Jang, M-H.,
Miyazaki, J. and Kiyono, H. 2002. IL-15 induced
CD8+ NK1.1+T cells in the development of small itestinal
inflammation in T3b-IL-15 Tg mice. J. Immunol. 169
: 460-468 |
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