6th The Awaji International Forum on Infection and Immunity  
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Hiroshi Kiyono,D.D.S., Ph.D.

Professor
Division of Mucosal Immunology
Department of Microbiology and Immunology
Institute of Medical Science
The University of Tokyo

Education

1972 D.D.S. Nihon University., School of Dentistry at Matsuudo Matsudo, Chiba, Japan
1983 Ph.D. Department of Pathology, Graduate School,University of Alabama at Birmingham, Medical Center, Birmingham, Alabama

Positions

1984-1987 Research and Clinical Assistant Professor, Department of Oral Biology University of Alabama at Birmingha, Medical Center
1986-1987 Visiting Senior Scientist, Infectious Disease Research Unit, Molecular Biology Section(with Dr. Thomas F. Meyer) Max-Planck Institute For Biology Tubingen, Federal Republic of Germany
1988-1990 Associate Professor, Departments of Oral Biology and Microbiology, University of Alabama at Birmingham, Medical Center
1991-2003 Professor, Departments of Oral Biology and Microbiology,University of Alabama at Birmingham, Medical Center
1992-1996 Co-Director, Immunobiology Vaccine Center, University of Alabama at Birmingham, Medical Center, Birmingham, Alabama
1994-2003 Professor and Chairman, Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
2004-present Adjunct Professor, Immunobiology Vaccine Center, University of Alabama at Birmingham,
Medical Center, Birmingham, Alabama
2000-present Professor and Director, Division of Mucosal Immunology, Department of Microbiology and Immunology,
The Institute of Medical Science, The University of Tokyo,Tokyo, Japan
2005-present Professor and Chairman, Department of Microbiology and Immunology,
The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
Selected Publications

1. Takagi, H., Hiroi, T., Yang, L., Tada, Y., Yuki, Y., Takamura, K., Ishimitsu, R., Kawauchi, H., Kiyono, H., and Takaiwa, F., 2005. A rice-based edible vaccine expressing multiple T cell epitopes induces oral tolerance for inhibition of Th2-mediated IgE responses. Proc Natl Acad Sci USA 102 : 17525-17530
2. Hino A., Fukuyama S., Kataoka K., Kweon MN., Fujihashi K., and Kiyono, H., 2005. Nasal IL-12p70 DNA prevents and treats intestinal allergic diarrhea. J Immunol. 174 : 7423-32
3. Kai, Y., Takahashi, I., Ishikawa, H., Hiroi, T., Mizushima, T., Matsuda, C., Kishi, D., Hamada, H., Tamagawa, H., Ito, T., Yoshizaki, K., Kishimoto, T., Matsuda, H., and Kiyono, H., 2005. Colitis in mice lacking the common cytokine receptor gamma chain is mediated by IL-6-producing CD4+ T cells. Gastroenterology 128 : 922-934
4. Kiyono, H., and Fukuyama, S. 2004. NALT-versus Peyer’s-patch-mediated mucosal immunity. 2004. Nature Rev. Immunol. 4 : 699-710
5. Jang, M-H., Kweon, M-N., Iwatani, K., Yamamoto, M., Terahara, K., Sasakawa, G., Suzuki, T., Nochi, T., Yokota, Y., Hiroi, T., Tamagawa, H., Iijima, H., Kunisawa, J., Yuki, Y., and Kiyono, H. 2004. Intestinal Villous M Cells: A new antigen entry site in the mucosal epithelium. Proc. Natl. Asso. Sci. 101 : 6110-6115
6. Shikina, T., Hiroi, T., Iwatani, K., Jan, M-H., Fukuyama, S., Tamura, M., Kubo, T., Ishikawa, H. and Kiyono, H. 2004. IgA class switch occurs in the organized nasopharynx and gut-associated lymphoid tissue, but not in the diffuse lamina proposal of airways and gut. J. Immunol. 172 : 6259-6264
7. 6. Park, E-J., Takahashi, I., Ikeda J., Kawahara, K., Okamoto, T., Kweon, M-N., Fukuyama, S., Groh, V., Spies, T., Obata, Y., Miyazaki, J. and Kiyono, H. 2003. Clonal expansion of double-positive (DP) IELs by MICA expressed in mouse small intestinal epithelium. J. Immunol. 171 : 4131-4139
8. Okuda, Y., Takahashi, I., Kim, J-K., Ohta,N., Iwatani, K., Kai, Y., Tamagawa, H., Hiroi, T., Kweon, M-N., Kawano, S., Sasaki, Y., Hori, M., Takeda, K., Akira, S. and Kiyono, H. 2003. Development of colitis in STAT6-deficient TCRα-/-mice: A potential of STAT6-independent IL-4 signaling for the generation of Th2-biased pathologic CD4+ββTcells. Am. J. Pathol. 162 : 263-271
9. Fukuyama, S., Hiroi, T., Yokota, Y., Rennert, P.D., Yanagita, M., Kinoshita, N., Terawaki, S., Shikina, T., Yamamoto, M., Kurono, Y. and Kiyono, H. 2002. NALT organogenesisn is independent of the IL-7R, LT 12/LTR and NIK signaling pathways but does require the Id2 gene and CD3- CD4+CD45+ cells. Immunity 17 : 31-40
10. Ohta, N., Hiroi, T., Kweon, M-N., Kinoshita, N., Jang, M-H., Miyazaki, J. and Kiyono, H. 2002. IL-15 induced CD8+ NK1.1+T cells in the development of small itestinal inflammation in T3b-IL-15 Tg mice. J. Immunol. 169 : 460-468
 
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