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Sven Hammerschmidt, Ph.D.
Head Junior Research Group Pneumococcal Pathogenesis, Research Center
for Infectious Diseases, University of Würzburg, Röntgenring 11,
97070 Würzburg, Germany |
CV
| 1987-1993 |
Study of Biology, Technical University of Braunschweig |
| 1993 |
Diploma thesis at the Institute for Medical Microbiology
(Head: Prof. D. Bitter-Suermann) in the group of Professor
M. Frosch, Medical School Hannover, |
| 1993-1995 |
PhD thesis at the Institute for Medical Microbiology, Medical
School Hannover |
| 1996 |
Dr. rer.nat. (PhD) |
| 1996-2003 |
Post-Doc at the German Centre for Biotechnology mbH, (GBF)
in Braunschweig, Germany; Leader of the group Streptococcus
pneumoniae in the department Microbial Pathogenicity
and Vaccine Research |
| 2002 |
Habilitation at the Technical University of Braunschweig.
Venia legendi for microbiology |
| Since 2003 |
Research Group Leader at the Research Center for Infectious
Diseases at the University of Würzburg |
| 2004 |
(re-)Habilitation at the University of Würzburg, lecturer
for Microbiology |
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Selected publications (since 2000)
2000-2003
| 1. |
Hammerschmidt, S., Tillig,
M.P., Wolff, S., Vaerman, J.-P., Chhatwal, G.S. 2000. Species-specific
binding of human secretory component to SpsA protein of Streptococcus
pneumoniae via a hexapeptide motif. Mol. Microbiol. 36:726-736. |
| 2. |
Bergmann, S., Rohde, M., Chhatwal, G.S., Hammerschmidt, S. 2001. alpha-Enolase of Streptococcus pneumoniae is a plasmin(ogen)-binding
protein displayed on the bacterial cell surface. Mol. Microbiol.
40:1273-1287. |
| 3. |
Holmes, A.R., McNab, R., Millsap, K.W., Rohde, M., Hammerschmidt, S., Mawdsley, J.L., Jenkinson, H.F. 2001. The pavA gene of
Streptococcus pneumoniae encodes a fibronectin-binding protein
that is essential for virulence. Mol. Microbiol. 41:1395-1408. |
| 4. |
Bergmann, S., Wild, D., Diekmann, O., Frank, R., Bracht,
D., Chhatwal, G.S., and Hammerschmidt, S. 2003. Identification
of a novel plasmin(ogen)-binding motif in surface displayed
alpha-enolase of Streptococcus pneumoniae. Mol. Microbiol.
49:411-423. |
2004
| 5. |
Elm, C., Braathen, R., Bergmann, S., Frank,
R., Vaerman, J.P., Kaetzel, C.S., Chhatwal, G.S., Johansen,
F.E., Hammerschmidt, S. 2004. Ectodomains 3 and 4 of human
polymeric Immunoglobulin receptor (hpIgR) mediate invasion
of Streptococcus pneumoniae into the epithelium. J. Biol.
Chem. 279:6296-6304. |
| 6. |
Bergmann, S., Rohde, M., Hammerschmidt, S. 2004. Glyceraldehyde-3-phosphate
dehydrogenase of Streptococcus pneumoniae is a surface-displayed
plasminogen-binding protein. Infect. Immun. 72:2416-2419. |
| 7. |
Dave, S., Carmicle, S., Hammerschmidt, S., Pangburn, M.K.,
McDaniel, L.S. 2004. Dual roles of PspC, a surface protein
of Streptococcus pneumoniae, in binding human secretory IgA
and factor H. J. Immunol. 173:471-477. |
| 8. |
Ehinger,S., Schubert,W.-D., Bergmann,S., Hammerschmidt,S.,
and Heinz,D.W. (2004) Crystal structure of plasmin(ogen)-binding
α-enolase from Streptococcus pneumoniae: evaluation
of plasmin(ogen)-binding sites J Mol Biol 343(4):997-1005. |
| 9. |
Opitz, B., Puschel, A., Schmeck, B., Hocke, A. C., Rosseau,
S., Hammerschmidt, S., Schumann, R.R., Suttorp, N., Hippenstiel,
S. 2004. Nucleotide-binding oligomerization domain proteins
are innate immune receptors for internalized Streptococcus
pneumoniae. J. Biol. Chem. 279:36426-36432. |
| 10. |
Schmeck, B., Gross, R., N'Guessan, P.D., Hocke, A.C., Hammerschmidt, S., Mitchell, T.J., Rosseau, S., Suttorp, N., Hippenstiel,
S. 2004. Streptococcus pneumoniae-induced caspase 6-dependent
apoptosis in lung epithelium. Infect. Immun. 72:4940-4947. |
2005
| 11. |
Pracht, D., Elm, C., Gerber, J., Bergmann,
S., Rohde, M., Seiler, M., Kim, K.S., Jenkinson, H.F., Nau,
R., Hammerschmidt, S. 2005. PavA of Streptococcus pneumoniae
modulates adherence, invasion, and meningeal inflammation
Infect.Immun. 73: 2680-2689. |
| 12. |
Hammerschmidt, S., Wolff, S., Hocke, A., Müller, E., Rohde,
M. 2005. Illustration of pneumococcal polysaccharide capsule
during adherence and invasion of epithelial cells. Infect.
Immun. 73: 4653-4667. |
| 13. |
Dje N'Guessan, P., Schmeck, B., Ayim, A., Hocke, A.C., Brell,
B., Hammerschmidt, S., Rosseau, S., Suttorp,
N., and Hippenstiel, S. (2005) Streptococcus pneumoniae
R6x-induced p38 MAPK and JNK-mediated caspase-dependent
apoptosis in human endothelial cells. Thromb Haemost
94(2): 295-303. |
| 14. |
Bergmann, S., Rohde, M., Preissner, K.T., and Hammerschmidt, S. (2005) Plasminogen-binding activity of pneumococcal enolase
promotes degradation of extracellular matrix, dissolution
of fibrin and enables transmigration of Streptococcus pneumonaie.
Thromb Haemost 94(2): 304-311. |
2006
| 15. |
Hermans, P.W.M., Adrian, P.V., Albert, C.,
Estevão, S., Hoogenboezem, T., Luijendijk, I.H.T.,
Kamphausen, T., and Hammerschmidt, S. (2006)
The streptococcal lipoprotein A (SlrA) is a functional peptidyl-prolyl
isomerase involved in pneumococcal colonisation J.Biol.Chem.
281: 968-976. |
| 16. |
Schmeck B., Huber S., Moog K., Zahlten J., Hocke A.C.,
Opitz B., Hammerschmidt S., Mitchell T.J., Kracht M., Rosseau
S., Suttorp N., Hippenstiel S. (2006) Pneumococci induced
TLR- and Rac1-dependent NF-{kappa}B-recruitment to the IL-8
promoter in lung epithelial cells. Am J Physiol Lung Cell
Mol Physiol. 290(4):L730-737. |
| 17. |
Kolberg, J., Aase, A., Bergmann, S., Herstad, T.K., Rødal,
G., Frank, R., Rohde, M., and Hammerschmidt, S.
(2006) Streptococcus pneumoniae enolase is important
for plasminogen binding despite low abundance of enolase protein
on the bacterial cell surface. Microbiology 152 (5):
1307-1317. |
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Reviews (peer reviewed) und Meeting Reports
Hammerschmidt, S, Hacker,
J., and Klenk, H.-D.. (2005) Threat of infection: Microbes
of high pathogenic potential-strategies for detection, control,
and eradication. Int. J. Med. Microbiol. 295: 141-151.
Hammerschmidt, S. (2006) Adherence molecules of pathogenic
pneumococci. Current Opinion in Microbiology 9:12-20.
Bergmann, S. and Hammerschmidt, S. (2006)
Versatility of pneumococcal surface proteins. Microbiology
152(2): 295-303. |
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