6th The Awaji International Forum on Infection and Immunity  
home english
Sven Hammerschmidt, Ph.D.

Head Junior Research Group Pneumococcal Pathogenesis, Research Center for Infectious Diseases, University of Würzburg, Röntgenring 11, 97070 Würzburg, Germany

1987-1993 Study of Biology, Technical University of Braunschweig
1993 Diploma thesis at the Institute for Medical Microbiology (Head: Prof. D. Bitter-Suermann) in the group of Professor M. Frosch, Medical School Hannover,
1993-1995 PhD thesis at the Institute for Medical Microbiology, Medical School Hannover
1996 Dr. rer.nat. (PhD)
1996-2003 Post-Doc at the German Centre for Biotechnology mbH, (GBF) in Braunschweig, Germany; Leader of the group Streptococcus pneumoniae in the department Microbial Pathogenicity and Vaccine Research
2002 Habilitation at the Technical University of Braunschweig. Venia legendi for microbiology
Since 2003 Research Group Leader at the Research Center for Infectious Diseases at the University of Würzburg
2004 (re-)Habilitation at the University of Würzburg, lecturer for Microbiology
Selected publications (since 2000)

1. Hammerschmidt, S., Tillig, M.P., Wolff, S., Vaerman, J.-P., Chhatwal, G.S. 2000. Species-specific binding of human secretory component to SpsA protein of Streptococcus pneumoniae via a hexapeptide motif. Mol. Microbiol. 36:726-736.
2. Bergmann, S., Rohde, M., Chhatwal, G.S., Hammerschmidt, S. 2001. alpha-Enolase of Streptococcus pneumoniae is a plasmin(ogen)-binding protein displayed on the bacterial cell surface. Mol. Microbiol. 40:1273-1287.
3. Holmes, A.R., McNab, R., Millsap, K.W., Rohde, M., Hammerschmidt, S., Mawdsley, J.L., Jenkinson, H.F. 2001. The pavA gene of Streptococcus pneumoniae encodes a fibronectin-binding protein that is essential for virulence. Mol. Microbiol. 41:1395-1408.
4. Bergmann, S., Wild, D., Diekmann, O., Frank, R., Bracht, D., Chhatwal, G.S., and Hammerschmidt, S. 2003. Identification of a novel plasmin(ogen)-binding motif in surface displayed alpha-enolase of Streptococcus pneumoniae. Mol. Microbiol. 49:411-423.

5. Elm, C., Braathen, R., Bergmann, S., Frank, R., Vaerman, J.P., Kaetzel, C.S., Chhatwal, G.S., Johansen, F.E., Hammerschmidt, S. 2004. Ectodomains 3 and 4 of human polymeric Immunoglobulin receptor (hpIgR) mediate invasion of Streptococcus pneumoniae into the epithelium. J. Biol. Chem. 279:6296-6304.
6. Bergmann, S., Rohde, M., Hammerschmidt, S. 2004. Glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pneumoniae is a surface-displayed plasminogen-binding protein. Infect. Immun. 72:2416-2419.
7. Dave, S., Carmicle, S., Hammerschmidt, S., Pangburn, M.K., McDaniel, L.S. 2004. Dual roles of PspC, a surface protein of Streptococcus pneumoniae, in binding human secretory IgA and factor H. J. Immunol. 173:471-477.
8. Ehinger,S., Schubert,W.-D., Bergmann,S., Hammerschmidt,S., and Heinz,D.W. (2004) Crystal structure of plasmin(ogen)-binding α-enolase from Streptococcus pneumoniae: evaluation of plasmin(ogen)-binding sites J Mol Biol 343(4):997-1005.
9. Opitz, B., Puschel, A., Schmeck, B., Hocke, A. C., Rosseau, S., Hammerschmidt, S., Schumann, R.R., Suttorp, N., Hippenstiel, S. 2004. Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae. J. Biol. Chem. 279:36426-36432.
10. Schmeck, B., Gross, R., N'Guessan, P.D., Hocke, A.C., Hammerschmidt, S., Mitchell, T.J., Rosseau, S., Suttorp, N., Hippenstiel, S. 2004. Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium. Infect. Immun. 72:4940-4947.

11. Pracht, D., Elm, C., Gerber, J., Bergmann, S., Rohde, M., Seiler, M., Kim, K.S., Jenkinson, H.F., Nau, R., Hammerschmidt, S. 2005. PavA of Streptococcus pneumoniae modulates adherence, invasion, and meningeal inflammation Infect.Immun. 73: 2680-2689.
12. Hammerschmidt, S., Wolff, S., Hocke, A., Müller, E., Rohde, M. 2005. Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cells. Infect. Immun. 73: 4653-4667.
13. Dje N'Guessan, P., Schmeck, B., Ayim, A., Hocke, A.C., Brell, B., Hammerschmidt, S., Rosseau, S., Suttorp, N., and Hippenstiel, S. (2005) Streptococcus pneumoniae R6x-induced p38 MAPK and JNK-mediated caspase-dependent apoptosis in human endothelial cells. Thromb Haemost 94(2): 295-303.
14. Bergmann, S., Rohde, M., Preissner, K.T., and Hammerschmidt, S. (2005) Plasminogen-binding activity of pneumococcal enolase promotes degradation of extracellular matrix, dissolution of fibrin and enables transmigration of Streptococcus pneumonaie. Thromb Haemost 94(2): 304-311.

15. Hermans, P.W.M., Adrian, P.V., Albert, C., Estevão, S., Hoogenboezem, T., Luijendijk, I.H.T., Kamphausen, T., and Hammerschmidt, S. (2006) The streptococcal lipoprotein A (SlrA) is a functional peptidyl-prolyl isomerase involved in pneumococcal colonisation J.Biol.Chem. 281: 968-976.
16. Schmeck B., Huber S., Moog K., Zahlten J., Hocke A.C., Opitz B., Hammerschmidt S., Mitchell T.J., Kracht M., Rosseau S., Suttorp N., Hippenstiel S. (2006) Pneumococci induced TLR- and Rac1-dependent NF-{kappa}B-recruitment to the IL-8 promoter in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 290(4):L730-737.
17. Kolberg, J., Aase, A., Bergmann, S., Herstad, T.K., Rødal, G., Frank, R., Rohde, M., and Hammerschmidt, S. (2006) Streptococcus pneumoniae enolase is important for plasminogen binding despite low abundance of enolase protein on the bacterial cell surface. Microbiology 152 (5): 1307-1317.
Reviews (peer reviewed) und Meeting Reports
Hammerschmidt, S, Hacker, J., and Klenk, H.-D.. (2005) Threat of infection: Microbes of high pathogenic potential-strategies for detection, control, and eradication. Int. J. Med. Microbiol. 295: 141-151.

Hammerschmidt, S. (2006) Adherence molecules of pathogenic pneumococci. Current Opinion in Microbiology 9:12-20.

Bergmann, S. and Hammerschmidt, S. (2006) Versatility of pneumococcal surface proteins. Microbiology 152(2): 295-303.
to top
Copyright (c) The 6th Awaji International Forum on Infection and Immunity. All rights reserved.
To do inspection and use comfortably, we are recommending a browser and the environment of the following versions.
Microsoft Internet Explorer 5.x or later version / Netscape Navigator 6.x or later version.
Please set JavaScript to "enable".