6th The Awaji International Forum on Infection and Immunity  
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Adolfo García-Sastre, Ph.D.

Professor
Department of Microbiology
Mount Sinai School of Medicine, USA
Education
1986 University of Salamanca, Spain B.S.
1990 University of Salamanca, Spain Ph.D.
1991-94 Mt Sinai School of Medicine, New York Postdoctoral

Positions

NATO Research Fellowship, December 1991 to March 1993.

Fulbright Research Fellowship, April 1993 to December 1994.

Research Assistant Professor, Dept. of Microbiology, Mount Sinai School of Medicine, New York, USA. Jan. 1995 to Dec. 1996.

Assistant Professor, Department of Microbiology, Mount Sinai School of Medicine, New York, USA. January 1997 to June 2001.

Associate Professor, Department of Microbiology, Mount Sinai School of Medicine, New York, USA. July 2001 to Dec. 2003.

Professor, Department of Microbiology, Mount Sinai School of Medicine, New York, USA. January 2004 to present.

Selected Publications (in chronological order) (out of 142)

110. O. Ebert, K. Shinozaki, C. Kournioti, M.-S. Park, A. García-Sastre & S. L. C. Woo: Syncytia induction enhances the oncolytic potential of vesicular stomatitis virus in virotherapy for cancer. Cancer Res. 64, 3265-3270 (2004).
111. M. L. Shaw, A. García-Sastre, P. Palese & and C. F. Basler: Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively. J. Virol, 78, 5633-5641 (2004).
112. A. García-Sastre: Identification and characterization of viral antagonists of type I interferon in negative-strand RNA viruses. Current Topics in Microbiology and Immunology, 283, 249-280 (2004).
113. W. H. Vecino, N. M. Quanquin, L. Martinez-Sobrido, A. Fernandez-Sesma, A. García-Sastre, W. R. Jacobs Jr. & G. J. Fennelly: Mucosal immunization with attenuated Shigella flexneri harboring an influenza hemagglutinin DNA vaccine protects mice against a lethal influenza challenge. Virology, 325, 192-199 (2004).
114. Y. Nakaya, T. Nakaya, M.-S. Park, J. Cros, J. Imanishi, P. Palese & A. García-Sastre: Induction of cellular immune responses to SIV gag by two recombinant negative strand RNA virus vectors. Journal of Virology, 78, 9366-9375 (2004).
115. J. C. Kash, C. F. Basler, A. García-Sastre, V. Carter, R. Billharz, D. E. Swayne, R. M. Przygodzki, J. K. Taubenberger, M. G. Katze & T. M. Tumpey: The global host immune response: pathogenesis and transcriptional profiling of type a influenza viruses expressing the HA and NA genes from the 1918 pandemic virus. Journal of Virology, 78, 9499-9511 (2004).
116. C. R. Baskin, A. García-Sastre, T. M. Tumpey, H. Bielefeldt-Ohmann, V. S. Carter, E. Nistal-Villán & M. G. Katze: Integration of clinical data, pathology, and cDNA microarrays in influenza virus-infected pigtailed macaques (Macaca nemestrina). Journal of Virology, 78, 10420-10432 (2004).
117. N. R. Donelan, B. Dauber, X. Wang, C. B. Basler, T. Wolff & A. García-Sastre: The N- and C-terminal domains of the NS1 protein of influenza B virus can independently inhibit IRF-3 and beta interferon promoter activation. Journal of Virology, 78, 11574-11582 (2004).
118. S. Jennings, L. Martinez-Sobrido, A. García-Sastre, F. Weber & G. Kochs. Thogoto virus ML protein suppresses IRF3 function. Virology, 331, 63-72 (2005).
119. F. Marcos, L. Ferreira, J. Cros, M.-S. Park, T. Nakaya, A. García-Sastre& E. Villar. Mapping of the RNA promoter of Newcastle disease virus. Virology, 331, 396-406 (2005).
120. M. Spiegel, A. Pichlmair, L. Martínez-Sobrido, J. Cros, A. García-Sastre, O. Haller & F. Weber. Inhibition of beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3. Journal of Virology, 79, 2079-2086 (2005).
121. C.F. Basler, A. García-Sastre& P. Palese. A novel paramyxovirus? Emerging Infectious Diseases, 11, 108-112 (2005).
122. J. F. Cros, A. García-Sastre& P. Palese. An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ribonucleoprotein. Traffic, 6, 205-213 (2005)
123. A. Bertolotti-Ciarlet., J. Smith., K. Strecker., J. Paragas., L. Altamura, J. McFalls, N. Frias-Staheli, A. García-Sastre, C. S. Schmaljohn & R. W. Doms. Cellular localization and antigenic characterization of Crimean-Congo hemorrhagic fever virus glycoproteins. Journal of Virology, 79, 6152-6161 (2005).
124. C. L. Efferson, K. Kawano, N. Tsuda, P. Palese, A. García-Sastre & C. G. Ioannides: Stimulation of human T cells by an influenza A vector expressing a CTL epitope from the HER-2/neu protooncogene results in higher numbers of antigen-specific TCRhi cells than stimulation with peptide. Divergent roles of IL-2 and IL-15. Anticancer Research, 25, 715-724 (2005).
125. A. Solórzano, R. J. Webby, K. M. Lager, B. H. Janke, A. García-Sastre& J. A. Richt: Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. Journal of Virology , 79, 7535-7543 (2005).
126. S. V. Bourmakina & A. García-Sastre: The morphology and composition of influenza A virus particles are not affected by low levels of M1 and M2 proteins in infected cells. Journal of Virology, 79, 7926-7932 (2005).
127. J. L. Muñoz-Jordán, M. Laurent-Rolle, J. Ashour, L Martínez-Sobrido, M. Ashok, W. I. Lipkin & A. García-Sastre: Inhibition of type I interferon signaling by the NS4B protein of flaviviruses. Journal of Virology, 79, 8004-8013 (2005).
128. M. Quinlivan, D. Zamarin, A. García-Sastre, A. Cullinane, T. Chambers, & P. Palese: Attenuation of equine influenza viruses through truncations of the NS1 protein. Journal of Virology, 79, 8431-8439 (2005).
129. L. Glaser, J. Stevens, D. Zamarin, I. A. Wilson, A. García-Sastre, T. M. Tumpey, C. F. Basler, J. K. Taubenberger & P. Palese: A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity. Journal of Virology, 79, 11533-11536 (2005).
130. A. M. Falcón, A. Fernandez-Sesma, Y. Nakaya, T. M. Moran, J. Ortín & A. García-Sastre: Attenuation and immunogenicity in mice of temperature-sensitive influenza viruses expressing truncated NS1 proteins. J. Gen. Virol., 86, 2817-2821 (2005).
131. D. Zamarin, A. García-Sastre, X. Xiao, R. Wang & P. Palese: Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. PLoS Pathogens, 1, 40-54 (2005).
132. T. M. Tumpey, C. F. Basler, P. V. Aguilar, H. Zeng, A. Solorzano, D. E. Swayne, N. J. Cox, J. M. Katz, J. K. Taubenberger, P. Palese & A. García-Sastre: Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science, 310, 77-80 (2005). This paper was selected “paper of the year 2005” by Lancet.
133. T. M.Tumpey, A. García-Sastre, J. K. Taubenberger, P. Palese, D. E. Swayne, M. J. Pantin-Jackwood, S. Schultz-Cherry, A. Solorzano, N. Van Rooijen, J. M. Katz & C. F. Basler: Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice. Journal of Virology, 79, 14933-14944 (2005).
134. J. Igietseme, F. Eko, Q. He, C. Bandea, W. Lubitz, A. García-Sastre & C. Black: Delivery of Chlamydia vaccines. Expert Opinion on Drug Delivery, 2, 549-562 (2005).
135. C. L. Efferson, N. Tsuda, K. Kawano, E. Nistal-Villán, S. Sellappan, D. Yu, J. L. Murray, A. García-Sastre& C. G. Ioannides: Prostate tumor cells infected with a recombinant influenza virus expressing a truncated NS1 protein activate cytolytic CD8+ cells to recognize non-infected tumor cells. Journal of Virology, 80, 383-394 (2006).
136. S. M. Carr, E. Carnero, A. García-Sastre, G. G. Brownlee & E. Fodor: Characterization of a mitochondrial targeting signal in the PB2 protein of influenza viruses. Virology, 344, 492-508 (2006).
137. L. Martinez-Sobrido, N. Gitiban, A. Fernandez-Sesma, J. Cros, S. E. Mertz, N. Jewell, S. Hammond, E. Flano, R. K. Durbin, A. García-Sastre, & J. E. Durbin: Protection against respiratory syncytial virus by a recombinant Newcastle disease virus vector. Journal of Virology, 80,1130-1139 (2006).
138 P. Palese, T. M. Tumpey & A. García-Sastre: What can we learn from reconstructing the extinct 1918 pandemic influenza virus? Immunity, 24, 121-124 (2006).
139. A. García-Sastre: Antiviral response in pandemic influenza viruses. Emerging Infectious Diseases, 12, 44-47 (2006).
140. L. Glaser, D. Zamarin, H. M. Acland, E. Spackman, P. Palese, A. García-Sastre& D. Tewari: Sequence analysis and receptor specificity of the hemagglutinin of a recent influenza H2N2 virus isolated from chicken in North America. Glycoconjugate Journal, 23, 93-99 (2006).
141. A. Fernandez-Sesma, S. Marukian, B. J. Ebersole, D.Kaminski, M.-S. Park, T. Yuen, S. C. Sealfon, A. García-Sastre & T. M. Moran: Influenza virus evades innate and adaptive immunity via the NS1 protein. Journal of Virology, in press.
142. A. García-Sastre& C. B. Biron: Type 1 interferons as pivots for virus-host interactions: A lesson in détente. Science, in press.
143. M-S. Park, J. Steel, A. García-Sastre, D. Swayne & P. Palese: Engineered viral vaccine constructs with dual specificity: Avian influenza and Newcastle disease. Proceedings of the National Academy of Sciences (U.S.A.), in press.
 
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