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| Cecil Czerkinsky, D.D.M., Ph.D.
Deputy Director-General for Laboratory Sciences
International Vaccine Institute |
Before joining the International Vaccine Institute, Dr.
Czerkinsky has been serving as the Director of the Division of Mucosal
Immunology and Vaccinology at INSERM (French National Institute
of Health and Medical Research) since 1997, focusing on basic mechanisms
governing induction of immunity in mucosal organs.
Dr. Czerkinsky received doctoral degrees from the University of
Lyon Medical and Dental Faculty in France, and the University of
Gothenburg Medical School in Sweden. He has more than 130 scientific
peer-reviewed publications in immunology and vaccinology with a
major focus on mucosal vaccines and immunomodulators.
Dr. Czerkinsky invented the ELISPOT, a method for monitoring immune
responses in humans and animals, which is used world-wide. His work
has been focused on basic immunological mechanisms pertaining to
vaccine development against infections, auto-immune disorders and
allergies. Dr. Czerkinsky holds several patents in these areas and
he is a co-founder of several biotechnology companies. |
Selected Publications
| 1. |
Czerkinsky, C., Nilsson, L-A., Nygren, H., Ouchterlony,
O., and Tarkowski, A. 1983. A solid phase enzyme-linked immunospot
(ELISPOT) assay for the enumeration of specific antibody-secreting
cells. J. Immunol. Methods 65:109. |
| 2. |
Czerkinsky, C., Prince, S.J., Russell, M.W., Moldoveanu,
Z., Jackson, S., Michalek, S.M., McGhee, J.R., and Mestecky,
J. 1987. IgA antibody-producing cells in peripheral blood
after antigen ingestion: evidence for a common mucosal immune
system in humans. Proc. Natl. Acad. Sci. (U.S.A.) 84:2449. |
| 3. |
Czerkinsky, C., Anderson, G., Nilsson, L-A., Eckre, H-P.,
Klareskog, L., and Ouchterlony, O. 1988. Reverse ELISPOT assay
for clonal analysis of cytokine production. I. Detection of
gamma interferon-secreting cells. J. Immunol. Methods 110:
29. |
| 4. |
Quiding, M., Nordstrom, I., Kilander, A.,Anderson, G., Hanson,
L.-A., Holmgren, J., and Czerkinsky, C. 1991. Intestinal immune
responses in humans. Oral cholera vaccination induces strong
intestinal antibody responses, gamma-interferon production,
and evokes local immunological memory. J. Clin. Invest. 88:143. |
| 5. |
Furuta Y., Eriksson K., Svennerholm B, Fredman P, Horal
P, Jeansson S, Vahlne A, Holmgren J and Czerkinsky C. 1994.
Infection of colonic and vaginal epithelial cells by the human
immunodeficiency virus type 1 is neutralized by antibodies
raised against conserved epitopes in the envelope glycoprotein
gp 120. Proc. Natl. Acad. Sci. (USA) 91: 12559-12563. |
| 6. |
Sun JB, Holmgren J, and Czerkinsky C. 1994. Cholera toxin
B subunit: an effective tansmucosal carrier delivery system
for induction of peripheral immunological tolerance. Proc.
Natl. Acad. Sci. (USA) 91:10795-99. |
| 7. |
Sun J-B, Rask C, Olsson T, Holmgren J, Czerkinsky C. 1996.
Treatment of experimental autoimmune encephalomyelitis by
feeding myelin basic protein conjugated to cholera toxin B
subunit. Proc. Natl. Acad. Sci. (USA), 93: 7196-7201. |
| 8. |
Bergerot I, Ploix C, Pedersen J, Moulin V, Rask C, Fabien
N, Lindblad M, Mayer A, Czerkinsky C. 1997. A cholera toxoid-insulin
conjugate as oral vaccine against spontaneous autoimmune diabetes.
Proc. Natl. Acad. Sci. (USA), 4610-4614. |
| 9. |
Quiding-Jarbrink M, Nordström I, Granström G, Kilander A,
Jertborn M, Butcher E, Lazarovits AJ, Holmgren J, Czerkinsky
C. 1997. Differential expression of tissue-specific adhesion
molecules on human circulating antibody-forming cells after,
systemic, enteric and nasal immunizations. A molecular basis
for the compartmentalization of effector B cell responses.
J. Clin. Invest. 99:1281-1286. |
| 10. |
Sun JB, Mielcarek N, Lakew M, Grzych JM, Capron A, Holmgren
J, Czerkinsky C 1999. Intranasal administration of a Schistosoma
mansoni glutathione S-transferase-cholera toxoid conjugate
vaccine evokes antiparasitic and antipathological immunity
in mice. J Immunol. 163:1045-52. |
| 11. |
Anjuere F, George-Chandy A, Audant F, Rousseau D, Holmgren
J, Czerkinsky C. 2003. Transcutaneous Immunization with Cholera
Toxin B Subunit Adjuvant Suppresses IgE Antibody Responses
Via Selective Induction of Th1 Immune Responses. J Immunol.
170:1586-92. |
| 12. |
Holmgren J, Harandi AM, Czerkinsky C. 2003. Mucosal adjuvants
and anti-infection and anti-immunopathology vaccines based
on cholera toxin, cholera toxin B subunit and CpG DNA. Expert
Rev Vaccines 2(2): 205-217 |
| 13. |
Anjuere F, Luci C, Lebens M, Rousseau D, Hervouet C, Milon
G, Holmgren J, Ardavin C, Czerkinsky C. 2004. In vivo adjuvant-induced
mobilization and maturation of gut dendritic cells after oral
administration of cholera toxin. J Immunol. 173:5103-11. |
| 14. |
Holmgren J and Czerkinsky C. 2005. Mucosal Immunity and
mucosal vaccines. Nature Med 11:45-53. |
| 15. |
Luci C, Hervouet C, Rousseau D, Czerkinsky C, Anjuere F.
2006. Dendritic cell-mediated induction of mucosal cytotoxic
responses following intravaginal immunization with the nontoxic
B subunit of cholera toxin.
J Immunol. 2006 176:2749-57. |
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