6th The Awaji International Forum on Infection and Immunity  
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Shizuo Akira, M.D., Ph.D.

Professor
Department of Host Defense,
Research Institute for Microbial Diseases,
Osaka University

Education:

1977 Graduated from Osaka University, School of Medicine (Obtained M.D.)
1977-1978 Clinical Training at Osaka University Hospital
1980-1984 Graduate student in the Department of Medicine, Osaka University, School of Medicine (Obtained Ph.D.)

Positions Held:

1978-1980 Physician in the Department of Internal Medicine, Sakai Municipal Hospital, Sakai, Osaka
1984-1985 Fellowship of the Japan Society for the Promotion of Science in the Institute for Molecular and Cellular Biology, Osaka University
1985-1987 Research Fellow in the Department of Microbiology and Immunology, California University, Berkeley
1987-1995 Research Associate in the Institute for Molecular and Cellular Biology, Osaka University from 1995 Associate Professor in the Institute for Molecular and Cellular Biology, Osaka University
1996-1999 Professor of Biochemistry, Hyogo College of Medicine
1996-2002 Research Head in CREST (Core Research for Evolutional Science and Technology) and SORST (Solution Oriented Research for Science and Technology) of Japan Science and Technology Corporation (JST)
1999-present Professor of Department of Host Defense, Research Institute for Microbial Diseases, Osaka University
2002-present Project Director of AKIRA Innate Immunity, ERATO (Exploratory Research for Advanced Technology) of Japan Science and Technology Corporation (JST)
Selected Publications

1. Uematsu S*, Jang MH*, Chevrier N, Guo Z, Kumagai Y, Yamamoto M, Kato H, Sougawa N, Matsui H, Kuwata H, Hemmi H, Coban C, Kawai T, Ishii KJ, Takeuchi O, Miyasaka M, Takeda K, Akira S (*equal contribution).
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c(+) lamina propria cells. Nat Immunol. 2006, 7:868-874
2. Kumar H*, Kawai T*, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S (*equal contribution).
Essential role of IPS-1 in innate immune responses against RNA viruses.
J Exp Med. 2006, 203: 538-547
3. Kato H*, Takeuchi O*, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis E Sousa C, Matsuura Y, Fujita T, Akira S (*equal contribution).
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature. 2006, 441:101-105
4. Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S. Cutting edge: roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol. 2006 176:4520-4.
5. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity.
Cell. 2006, 124:783-801.
6. Kawai T, Akira S. Innate immune recognition of viral infection.Nat Immunol. 2006, 7:131-7.
7. Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol. 2005, 7: 40-48
8. Sato S*, Sanjo H*, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S (*equal contribution). Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol. 2005, 6, 1087-1095
9. Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, Ishii KJ, Takeuchi O, Akira S. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol. 2005, 6:981-8.
10. Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira S. Cell Type-Specific Involvement of RIG-I in Antiviral Response. Immunity. 2005, 23:19-28.
11. Kawai T, Akira S. Pathogen recognition with Toll-like receptors. Curr Opin Immunol. 2005, 17:338-344.
12. Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, Matsuda M, Coban C, Ishii KJ, Kawai T, Takeuchi O, Akira S. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J Exp Med. 2005, 201, 915-923
13. Hirotani T, Yamamoto M, Kumagai Y, Uematsu S, Kawase I, Takeuchi O, Akira S. Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta. Biochem Biophys Res Commun. 2005, 328:383-92.
14. Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med. 2005, 201:19-25.
15. Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, Terai K, Matsuda M, Inoue JI, Uematsu S, Takeuchi O, Akira S. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol. 2004, 5: 1061-1068
16. Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S. Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature 2004, 430:218-22.
17. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 4:499-511.
18. Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H, Kawai T, Hoshino K, Takeda K, Akira S. The Roles of Two IkappaB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection. J Exp Med. 2004, 199:1641-50.
 
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