| |
Shizuo Akira, M.D., Ph.D.
Professor
Department of Host Defense,
Research Institute for Microbial Diseases,
Osaka University |
 |
Education:
| 1977 |
Graduated from Osaka University, School of Medicine
(Obtained M.D.) |
| 1977-1978 |
Clinical Training at Osaka University Hospital |
| 1980-1984 |
Graduate student in the Department of Medicine, Osaka University,
School of Medicine (Obtained Ph.D.) |
|
Positions Held:
| 1978-1980 |
Physician in the Department of Internal Medicine,
Sakai Municipal Hospital, Sakai, Osaka |
| 1984-1985 |
Fellowship of the Japan Society for the Promotion of Science
in the Institute for Molecular and Cellular Biology, Osaka
University |
| 1985-1987 |
Research Fellow in the Department of Microbiology and Immunology,
California University, Berkeley |
| 1987-1995 |
Research Associate in the Institute for Molecular and Cellular
Biology, Osaka University from 1995 Associate Professor in
the Institute for Molecular and Cellular Biology, Osaka University
|
| 1996-1999 |
Professor of Biochemistry, Hyogo College of Medicine |
| 1996-2002 |
Research Head in CREST (Core Research for Evolutional Science
and Technology) and SORST (Solution Oriented Research for
Science and Technology) of Japan Science and Technology Corporation
(JST) |
| 1999-present |
Professor of Department of Host Defense, Research Institute
for Microbial Diseases, Osaka University |
| 2002-present |
Project Director of AKIRA Innate Immunity, ERATO (Exploratory
Research for Advanced Technology) of Japan Science and Technology
Corporation (JST) |
|
Selected Publications
| 1. |
Uematsu S*, Jang MH*, Chevrier N, Guo Z, Kumagai
Y, Yamamoto M, Kato H, Sougawa N, Matsui H, Kuwata H, Hemmi
H, Coban C, Kawai T, Ishii KJ, Takeuchi O, Miyasaka M, Takeda
K, Akira S (*equal contribution).
Detection of pathogenic intestinal bacteria by Toll-like receptor
5 on intestinal CD11c(+) lamina propria cells. Nat Immunol.
2006, 7:868-874 |
| 2. |
Kumar H*, Kawai T*, Kato H, Sato S, Takahashi K, Coban C,
Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira
S (*equal contribution).
Essential role of IPS-1 in innate immune responses against
RNA viruses.
J Exp Med. 2006, 203: 538-547 |
| 3. |
Kato H*, Takeuchi O*, Sato S, Yoneyama M, Yamamoto M, Matsui
K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu
K, Tsujimura T, Koh CS, Reis E Sousa C, Matsuura Y, Fujita
T, Akira S (*equal contribution).
Differential roles of MDA5 and RIG-I helicases in the recognition
of RNA viruses. Nature. 2006, 441:101-105 |
| 4. |
Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira
S. Cutting edge: roles of caspase-8 and caspase-10
in innate immune responses to double-stranded RNA. J Immunol.
2006 176:4520-4. |
| 5. |
Akira S, Uematsu S, Takeuchi O. Pathogen
recognition and innate immunity.
Cell. 2006, 124:783-801. |
| 6. |
Kawai T, Akira S. Innate immune recognition
of viral infection.Nat Immunol. 2006, 7:131-7. |
| 7. |
Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita
F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto
M, Uematsu S, Kawai T, Takeuchi O, Akira S.
A Toll-like receptor-independent antiviral response induced
by double-stranded B-form DNA. Nat Immunol. 2005, 7: 40-48 |
| 8. |
Sato S*, Sanjo H*, Takeda K, Ninomiya-Tsuji J, Yamamoto
M, Kawai T, Matsumoto K, Takeuchi O, Akira S
(*equal contribution). Essential function for the kinase TAK1
in innate and adaptive immune responses. Nat Immunol. 2005,
6, 1087-1095 |
| 9. |
Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H,
Ishii KJ, Takeuchi O, Akira S. IPS-1, an
adaptor triggering RIG-I- and Mda5-mediated type I interferon
induction. Nat Immunol. 2005, 6:981-8. |
| 10. |
Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui
K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira
S. Cell Type-Specific Involvement of RIG-I in Antiviral
Response. Immunity. 2005, 23:19-28. |
| 11. |
Kawai T, Akira S. Pathogen recognition
with Toll-like receptors. Curr Opin Immunol. 2005, 17:338-344.
|
| 12. |
Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita
F, Matsuda M, Coban C, Ishii KJ, Kawai T, Takeuchi O, Akira
S. Interleukin-1 receptor-associated kinase-1 plays
an essential role for Toll-like receptor (TLR)7- and TLR9-mediated
interferon-{alpha} induction. J Exp Med. 2005, 201, 915-923
|
| 13. |
Hirotani T, Yamamoto M, Kumagai Y, Uematsu S, Kawase I,
Takeuchi O, Akira S. Regulation of lipopolysaccharide-inducible
genes by MyD88 and Toll/IL-1 domain containing adaptor inducing
IFN-beta. Biochem Biophys Res Commun. 2005, 328:383-92. |
| 14. |
Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S,
Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira
S. Toll-like receptor 9 mediates innate immune activation
by the malaria pigment hemozoin. J Exp Med. 2005, 201:19-25. |
| 15. |
Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M,
Terai K, Matsuda M, Inoue JI, Uematsu S, Takeuchi O, Akira
S. Interferon-alpha induction through Toll-like receptors
involves a direct interaction of IRF7 with MyD88 and TRAF6.
Nat Immunol. 2004, 5: 1061-1068 |
| 16. |
Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino
K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T,
Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira
S. Regulation of Toll/IL-1-receptor-mediated gene
expression by the inducible nuclear protein IkappaBzeta. Nature
2004, 430:218-22. |
| 17. |
Akira S, Takeda K. Toll-like receptor signalling.
Nat Rev Immunol. 4:499-511. |
| 18. |
Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo
H, Kawai T, Hoshino K, Takeda K, Akira S.
The Roles of Two IkappaB Kinase-related Kinases in Lipopolysaccharide
and Double Stranded RNA Signaling and Viral Infection. J Exp
Med. 2004, 199:1641-50. |
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